Salicylic acid supramolecular preparation and preparation method thereof

Abstract

The invention relates to a salicylic acid supramolecular preparation and a preparation method thereof. The salicylic acid supramolecular preparation is characterized by consisting of the following components in percentage by mass: 15 to 50% of salicylic acid, 18 to 25% of polyquaternium-61, 15 to 35% of polyhydric alcohol and 15 to 25% of montmorillonite, wherein the polyhydric alcohol is one or amixture of isohexanediol and isoprene glycol in any ratio. According to the invention, the obtained salicylic acid supramolecular preparation has the advantages of good water dispersibility, low irritation, high bioavailability and the like, and is convenient to add into products such as medical dressings, cosmetics and the like.

Description

technical field [0001] The invention relates to the technical field of cosmetic preparation, in particular to a salicylic acid supramolecular preparation and a preparation method thereof. Background technique [0002] Salicylic acid is a type of beta-hydroxy acid. Salicylic acid has functions such as keratin regulation, pore unclogging, pore shrinkage, oil control, and anti-inflammation, and is widely used in cosmetics. However, salicylic acid has the following application problems: the solubility of salicylic acid in water at 20 °C is 2 g / L, and it is almost insoluble in water. It is easy to form crystals and precipitate when directly added to skin care formulas, reducing its bioavailability; To ensure the stability of the product and avoid the crystallization of salicylic acid, in practical applications, it is often necessary to use a large amount of alcohol to dissolve it first, and then add a large amount of surfactant to help it dissolve in water. However, the high co...

AI Technical Summary

Problems solved by technology

However, salicylic acid has the following application problems: the solubility of salicylic acid in water at 20 °C is 2 g / L, and it is almost insoluble in water. It is easy to form crystals and precipitate when directly added to skin care formulas, reducing its bioavailability; To ensure the stability of the product and avoid the crystallization of salicylic acid, in practical applications, it is often necessary to use a large amount of alcohol to dissolve it first, and then add a large amount of surfactant to help it dissolve in water

Salicylic acid derivatives include betaine salicylate, octanoyl salicylate, tridecyl salicylate, etc. These substances have been chemically modified to improve their solubility or irritation to a certain extent. However, compared with salicylic acid, these salicylic acid derivatives are greatly reduced in efficacy

The Chinese invention patent "Preparation Method of Salicylic Acid Liposome and Its Series of External Preparations and Its Application in Acne Treatment" (ZL 201010146934.8) uses liposome as the drug delivery system to encapsulate salicylic acid, and then endow it with emulsion, External dosage forms such as gels and creams can reduce the irritation of salicylic acid to the skin, prolong the action time, and have good curative effect, but for water-based products, especially transparent system products, there are still problems that are not easy to apply. question

Chinese invention patent "a composite wall material microcapsule loaded with salicylic acid and its preparation method" (ZL201810022817.7) uses the inclusion complexation method to wrap β-cyclodextrin and carboxymethyl cellulose on the surface of salicylic acid The wall material compounded with sodium or ethyl cellulose finally obtains a composite wall material microcapsule loaded with salicylic acid, thereby improving the dispersibility of salicylic acid in water, but the capsule formed by it is relatively hard and has hard Grainy texture, affecting the applicability of cosmetics

Chinese invention patent "Water-Soluble Supramolecular Complex" (ZL 201580063447.6) uses a water-soluble block copolymer and at least one associated gel adjuvant to form a water-soluble supramolecular complex of salicylic acid and its derivatives, effectively solving the problem of The precipitation of salicylic acid is a problem, but the water-soluble supramolecular complex is a paste substance. When it is added to cosmetics, its immediate application feeling is very thick, and the skin feels sticky after application, which directly affects the pleasant use that cosmetics should have. sense

Images