Application of zeartinib in preparation of drugs for treating pulmonary fibrosis diseases

A technology for pulmonary fibrosis and disease, applied in the field of application of zanubrutinib in the preparation of drugs for the treatment of pulmonary fibrosis

Active Publication Date: 2021-02-23
TIANJIN JIKUN MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no reports of zanubrutinib slowing down pulmonary fibrosis

Method used

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  • Application of zeartinib in preparation of drugs for treating pulmonary fibrosis diseases
  • Application of zeartinib in preparation of drugs for treating pulmonary fibrosis diseases
  • Application of zeartinib in preparation of drugs for treating pulmonary fibrosis diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Zanubrutinib slows down bleomycin-induced pulmonary fibrosis in mice

[0030] Animal model preparation: male C57BL / 6J wild-type mice (8-10 weeks old), anesthetized mice, and invasively injected 2U / Kg bleomycin into the trachea.

specific Embodiment approach

[0031] The specific implementation method is as follows: weigh and record after anesthetizing the mouse, fix the mouse on the operating table, disinfect the neck with 75% (v / v) alcohol, and cut a vertical wound of about 1 cm in the neck of the mouse with a scalpel. Use microscopic tweezers to separate the tissues to expose the trachea, insert the syringe into the trachea through the gap between the cartilage rings of the trachea towards the end of the heart, then slowly inject 2 U / kg of bleomycin saline solution in a volume appropriate to its body weight, and immediately put the animal upright And rotate left and right, so that the liquid medicine is evenly distributed in the lungs.

[0032] The blank control group was injected with the same volume of normal saline (0.9% (w / v) NaCl (sodium chloride)).

[0033] Administration in groups: Zenubrutinib treatment refers to giving mice 10 mg / kg of zanubrutinib by intragastric administration every day on the 7th to 14th day of bleomy...

Embodiment 2

[0035] The same as in Example 1, the difference is: in group administration: on the 7th-14th day of bleomycin treatment, mice were given 5 mg / kg zanubrutinib by intragastric administration every day, and the corresponding solvent saline was used as a control , 14 days after bleomycin treatment, lung collagen content and fibrosis severity were detected.

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Abstract

The embodiment of the invention provides an application of zeartinib in preparation of drugs for treating pulmonary fibrosis diseases, and the structural formula of zeartinib is shown in the specification. Experiments show that zeartinib has a good effect on pulmonary fibrosis, has no adverse reaction, can slow down bleomycin-induced pulmonary fibrosis in mice, and provides a good application prospect for the treatment, alleviation or improvement of pulmonary fibrosis diseases.

Description

technical field [0001] The invention relates to a use of zanubrutinib, in particular to the application of zanubrutinib in the preparation of medicines for treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis (PF) is the end-stage clinical manifestation of many pulmonary interstitial diseases with different etiologies, characterized by persistent alveolar damage, fibroblast proliferation, and massive extracellular matrix (ECM) deposition , leading to varying degrees of inflammation and fibrosis in the alveoli and interstitium of the lungs, leading to structural destruction of the lungs and respiratory failure, so it is also called interstitial lung disease (Interstitial Lung Disease, ILD) or diffuse parenchymal Lung disease (Diffuse Parenchymal Lung Disease, DPLD). [0003] Idiopathic pulmonary fibrosis (IPF) belongs to the idiopathic interstitial pneumonia (IIP) group in the family of interstitial lung diseases (ILDs). IPF is the most common and s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P11/00
CPCA61K31/519A61P11/00
Inventor 杨诚周红刚李霄鹤张亮李建伦东超
Owner TIANJIN JIKUN MEDICAL TECH CO LTD
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