Oral ulcer gel as well as preparation method and application thereof

A technology for oral ulcers and gels, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. It has the therapeutic effect and other problems, and achieves the effect of good drug sustained release, excellent effect and significant coagulation.

Active Publication Date: 2021-03-02
NANJING TZONE BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Except that the patch can prolong the time of the drug on the oral ulcer surface, other dosage forms are easily washed away by food or the patient's own saliva, and the disadvantage of the patch is that it is small in size, which is inconvenient to use for patients with large oral ulcers. Used during normal speaking and eating, easily carried away by the tongue
Oral ulcer gels with simple physical barriers have good coagulation and adhesion, but do not have a good sustained-release effect of drugs. Therefore, this type of oral ulcer gels do not have therapeutic effects but pure physica...

Method used

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  • Oral ulcer gel as well as preparation method and application thereof
  • Oral ulcer gel as well as preparation method and application thereof
  • Oral ulcer gel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] This embodiment provides a kind of oral ulcer gel, and its preparation raw material comprises by weight: 45.75 parts of glyceryl dioleate, 39 parts of soybean lecithin, 0.2 part of Tween 80, 0.1 part of cetyl chloramine, 10 parts of ethanol 0.15 parts of propylene glycol, 2 parts of polyvinyl alcohol, 5 parts of sodium carboxymethylcellulose, and 0.1 part of menthol.

[0065] Its preparation method is as follows:

[0066] (1) Mix glyceryl dioleate and soybean lecithin, heat to 80°C to dissolve, and stir at a speed of 40 rpm for 30 minutes;

[0067] (2) Mix the product of step (1) with ethanol, cool down to 30°C, and stir at a speed of 40rpm for 10min;

[0068] (3) Mix the product of step (2) with the premixture of Tween 80 and menthol, and stir at 25°C at a speed of 40rpm for 10min;

[0069] (4) Mix the product of step (3) with the premixed solution of cetyl chloramine and propylene glycol, and stir at a speed of 40 rpm for 10 min at 25° C.;

[0070] (5) The product ...

Embodiment 2

[0072] This embodiment provides a kind of oral ulcer gel, and its preparation raw material comprises by weight part: 45.75 parts of glycerol monooleate, 39 parts of soybean lecithin, 0.2 part of Tween 60, 0.1 part of metronidazole, 10 parts of ethanol , 0.15 parts of propylene glycol, 2 parts of polyvinylpyrrolidone, 5 parts of hydroxypropyl methylcellulose, and 0.1 part of sodium saccharin.

[0073] Its preparation method is as follows:

[0074] (1) Mix glycerol monooleate and soybean lecithin, heat to 85°C to dissolve, and stir at a speed of 30rpm for 35min;

[0075] (2) Mix the product of step (1) with ethanol, cool down to 25°C, and stir at a speed of 30rpm for 15min;

[0076] (3) Mix the product of step (2) with the premixture of Tween 60 and sodium saccharin, and stir at 25°C at a speed of 30rpm for 15min;

[0077] (4) Mix the product of step (3) with the premixed solution of metronidazole and propylene glycol, and stir at 25° C. at a speed of 30 rpm for 15 minutes;

[...

Embodiment 3

[0080] The present embodiment provides a kind of oral ulcer gel, and its preparation raw material comprises by weight part: 45.75 parts of glycerol monolinoleate, 39 parts of soybean lecithin, 0.2 part of Tween 80, 0.1 part of dexamethasone acetate, ethanol 10 parts, 0.15 parts of propylene glycol, 2 parts of polyvinyl alcohol, 5 parts of hydroxyethyl cellulose, 0.1 part of maltodextrin.

[0081] Its preparation method is as follows:

[0082] (1) Mix glycerol monolinoleate and soybean lecithin, heat to 75°C to dissolve, and stir at a speed of 50rpm for 25min;

[0083] (2) Mix the product of step (1) with ethanol, cool down to 20°C, and stir at a speed of 50rpm for 5min;

[0084] (3) Mix the product of step (2) with the premixture of Tween 80 and maltodextrin, and stir at 50 rpm for 5 minutes at 20°C;

[0085] (4) Mix the product of step (3) with the premixed solution of dexamethasone acetate and propylene glycol, and stir at 20° C. at a speed of 50 rpm for 5 minutes;

[008...

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Abstract

The invention relates to oral ulcer gel as well as a preparation method and application thereof. The oral ulcer gel is prepared from the following raw materials: a liquid crystal gel precursor substance, a drug, a solvent, a film-forming agent, an adhesive and a taste regulator; and the liquid crystal gel precursor substance comprises an olein compound, lecithin and an emulsifier. According to theoral ulcer gel disclosed by the invention, a liquid crystal slow-release system prepared from olein compounds and lecithin is used for wrapping the common oral treatment drug by utilizing a lipid liquid crystal nano-wrapping technology with relatively high biological safety, and with the film-forming agent, the adhesive and the taste regulator, the whole gel system has good coagulability and adhesion, also has a very good drug slow release effect, and has very high biological safety.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to an oral ulcer gel and its preparation method and application, in particular to an oral ulcer gel based on a liquid crystal slow-release system and its preparation method and application, especially to an oral ulcer gel with high biological safety 1. Oral ulcer gel with good water absorption, good coagulation and good adhesion, and its preparation method and application. Background technique [0002] According to literature reports, at least 30%-40% of patients develop oral mucositis on the 5th to 10th day of chemotherapy, which is usually manifested clinically as oral pain, affecting patients’ eating, affecting patients’ language communication, and affecting patients’ sleep. The quality of life of the patient is reduced, and even hinders the further treatment of the patient. Therefore, the treatment of chemotherapy-related oral mucositis has important clinical significance. [0003] Dr...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/127A61K47/14A61K47/24A61K45/00A61P1/02
CPCA61K9/006A61K9/1274A61K45/00A61K47/14A61K47/24A61P1/02
Inventor 徐林杨菲霏宁涛朱文军马旭
Owner NANJING TZONE BIOLOGICAL SCI & TECH
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