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Application of pharmaceutical composition in preparation of medicines for preventing or treating kidney diseases

A kidney disease and composition technology, used in the field of preparing drugs for preventing or treating kidney disease, can solve problems such as insufficiently satisfying clinical treatment needs, blocking kidneys, etc., so as to delay the progression of kidney disease, improve kidney function and improve kidney damage. Effect

Active Publication Date: 2021-03-02
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the above-mentioned existing drugs for the treatment of kidney diseases are mainly aimed at specific symptoms, it is difficult to substantially block the progression of renal insufficiency, and cannot fully meet the needs of clinical treatment
In addition, the side effects of long-term use of drugs have also become a real problem. For example, glucocorticoids can cause bone marrow suppression, liver function damage, sexual function damage, gastrointestinal dysfunction and other obvious side effects. It is recommended to reduce their dosage as much as possible or stop using them in clinical practice. Effective drug for kidney disease needs further development

Method used

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  • Application of pharmaceutical composition in preparation of medicines for preventing or treating kidney diseases
  • Application of pharmaceutical composition in preparation of medicines for preventing or treating kidney diseases
  • Application of pharmaceutical composition in preparation of medicines for preventing or treating kidney diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Embodiment 1 Adriamycin Nephropathy Model Mouse Treatment Result

[0079] 1. Preparation of animal models

[0080] Male BALB / c mice (body weight 20-25g) were controlled at a constant room temperature of 20-23°C, 12 hours of light and 12 hours of darkness cycle conditions, while free to eat and drink, by giving a one-time tail vein injection of 10.4mg / kg doxorubicin (Adriamycin, dissolved in normal saline) to prepare a mouse model of doxorubicin nephropathy, and the normal group was given a one-time tail vein injection of the same amount of normal saline, and the test results proved that the kidney injury model was successfully established. Among them, Adriamycin was purchased from Sigma Company in the United States, and BALB / c mice were purchased from the Experimental Animal Center of Southern Medical University. Animal experiments were carried out in strict accordance with the animal ethics guidelines and regulations of Guangzhou University of Traditional Chinese Medi...

Embodiment 2

[0098] Embodiment 2 Diabetes model mouse treatment result

[0099] 1. Preparation of animal models

[0100] Male C57BL / 6 mice were controlled at a constant room temperature of 20-23°C, with a 12-hour light and 12-hour dark cycle, and free access to food and water. The type 1 diabetes mouse model was induced by intraperitoneal injection of 55 mg / kg streptozotocin (STZ, dissolved in citrate buffer) for 5 consecutive days, and the fasting blood glucose was measured 9 days after the last STZ injection, and the test results It proves that diabetes modeling is successful.

[0101] During the preparation of the above animal model: male C57BL / 6 mice (body weight 22-26 g) were purchased from the Guangdong Medical Experimental Animal Center. Animal experiments were carried out in strict accordance with the animal ethics guidelines and regulations of Guangzhou University of Traditional Chinese Medicine; STZ was purchased from Sigma Corporation of the United States.

[0102] 2. Group d...

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Abstract

The present invention provides an application of a pharmaceutical composition in preparation of drugs for prevention or treatment on kidney diseases, the pharmaceutical composition comprises at leastone mitochondrial uncoupling agent and at least one artemisinin compound, and the pharmaceutical composition can effectively reduce urine total protein, albumin and urine H2O2 content, reduce serum creatinine and serum urea nitrogen levels, and improve kidney disease resistance. The traditional Chinese medicine composition has the effects of reducing urine excretion of NAG, NGAL and Kim1, effectively improving renal functions and glomerulus and renal tubule injuries, effectively improving abnormal lipid metabolism caused by kidney injuries and diabetic nephropathy, playing a role in protectingkidneys, delaying the progress of kidney diseases and effectively preventing or treating the kidney diseases.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the use of a pharmaceutical composition in the preparation of drugs for preventing or treating kidney diseases. Background technique [0002] The kidney is an important organ of the human body. Its basic function is to maintain the homeostasis of the body's internal environment by forming urine, such as 1) removing metabolic wastes in the body, such as creatinine, urea nitrogen, etc.; 2) regulating body water, electrolytes, acid-base balance. In addition, the kidney can also secrete renin, erythropoietin, active vitamin D3, prostaglandins, kinins, etc. It is the degradation site of some endocrine hormones in the body and the target organ of extrarenal hormones. These functions of the kidneys ensure the stability of the internal environment of the body and enable the body's metabolism to proceed normally. [0003] Kidney disease is a type of disease that affects the kidneys ...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/167A61K31/357A61P13/12
CPCA61K45/06A61K31/167A61K31/357A61P13/12A61K2300/00
Inventor 韩鹏勋孙惠力邵牧民翁文慈余学问王太芬
Owner SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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