A kind of traditional Chinese medicine composition and its preparation method and application

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its preparation and application, can solve the problems of undisclosed lily and Anemarrhena antidepressants, etc., to increase the concentration of central monoamine neurotransmitters, increase the concentration of dopamine, significant effect

Active Publication Date: 2022-04-15
SHANGHAI CHANGZHENG HOSPITAL
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] How to use Lily and Anemarrhena to prepare antidepressants is not disclosed in the prior art

Method used

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  • A kind of traditional Chinese medicine composition and its preparation method and application
  • A kind of traditional Chinese medicine composition and its preparation method and application
  • A kind of traditional Chinese medicine composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] Embodiment: the preparation of antidepressant Chinese medicine composition (zhimubaihe oral liquid)

[0019] 1 material

[0020] 1.1 Instruments Agilent1200 series high performance liquid chromatography (Agilent, the United States); desktop high-speed refrigerated centrifuge (Eppendorf, Germany); CPA225D one hundred thousandth balance (Sartorius, Germany); WL-901 vortex mixer (Qilin Bell Instrument Manufacturing Co., Ltd., Haimen); SK7200H Ultrasonic Apparatus (Kedao Ultrasonic Instrument Co., Ltd., Shanghai); SHH-250SD Drug Stability Test Chamber (Chongqing Yongsheng Experimental Instrument Factory, Chongqing, temperature: 15℃~65℃±2 ℃, humidity: 15% ~ 95% ± 5%).

[0021] 1.2 The test drug Zhimu Baihe Oral Liquid (Anemarrhena and Lily Chinese herbal medicines were purchased from Tongling Hetian Chinese Herbal Pieces Co., Ltd., in line with the standards of the "Chinese Pharmacopoeia" 2015 edition, and Zhimu Baihe Oral Liquid was purchased from the Second Affiliated Hos...

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PUM

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Abstract

The invention provides a Chinese medicine composition and its preparation method and application, wherein the best conditions for the preparation method of the Chinese medicine composition adopt the method of water extraction and alcohol precipitation: the amount of water added is 10 times, the number of times of extraction is 2 times, and the extraction time is 10 times. For 2 hours, the concentration of alcohol precipitation was 60%. Anemarrhena lily: Anemarrhena lily oral liquid with an optimal mass ratio of 1:2 prepared by adopting the above technical scheme has a high content of active ingredient mangiferin and has antidepressant curative effect, and can be used to prepare antidepressant drugs.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method and application thereof. Background technique [0002] Depression, as a mental disease that seriously affects human physical and mental health, is rapidly increasing at an annual growth rate of 113%. According to the global burden of disease statistics, using disability-adjusted life years as the indicator of disease burden, mental / neurological diseases rank first in the burden of disease, and depression ranks first in neurological diseases; according to the statistics of the World Psychiatric Association, as of now The global incidence rate of depression is 4.2%, and China has reached 6.9%. According to the prediction of the World Health Organization, depression will become the second largest disease causing human death and disability by 2020. [0003] Baihe Zhimu Decoction first appeared in Zhang Zhongjing's "Synopsis of the Golden Chamber·The Syndrome and T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8967A61K9/08A61P25/24
CPCA61K36/8964A61K36/8967A61K9/0095A61P25/24A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 朴淑娟陈万生庞涛陆文铨蔺红伟
Owner SHANGHAI CHANGZHENG HOSPITAL
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