Probiotic combined with atomized rhizoma bletillae polysaccharide-chitosan composite hydrogel and preparation method and purpose thereof

A composite hydrogel and oxidized whitening technology, applied in bandages, medical science, etc., can solve the problems of cytotoxicity hindering the development, and achieve the effects of protecting and healing, obvious scars, and preventing wound infection

Pending Publication Date: 2021-03-16
SOUTHWEST UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, its development has been hindered by problems such as bacterial resistance and cytotoxicity.

Method used

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  • Probiotic combined with atomized rhizoma bletillae polysaccharide-chitosan composite hydrogel and preparation method and purpose thereof
  • Probiotic combined with atomized rhizoma bletillae polysaccharide-chitosan composite hydrogel and preparation method and purpose thereof
  • Probiotic combined with atomized rhizoma bletillae polysaccharide-chitosan composite hydrogel and preparation method and purpose thereof

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Embodiment 1

[0090] Example 1, the preparation of probiotics of the present invention combined with oxidized white and polysaccharide-chitosan composite hydrogel 1. Extraction, separation and purification of white and polysaccharide

[0091] Bletilla striata polysaccharide (BSP) was prepared according to the method described in the literature (Qu Y, et al. Optimization of infrared-assisted extraction of Bletilla striata polysaccharides based on response surface methodology and their antioxidant activities. Carbohydrate Polymers, 2016, 148:345-353.) . The specific preparation method is as follows:

[0092] Crush the dried white and tubers, sieve, degrease with petroleum ether (temperature: 60-90°C), then use ethanol (use 10mL of 95% ethanol per gram of powder) at 70°C to reflux twice for 2 hours each time, and finally filter , and the filter cake is dried to obtain a pretreated dry powder. Add the pretreated dry powder and water into the beaker at a solid-to-liquid ratio of 1:40 (g / mL), s...

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Abstract

The invention provides a probiotic combined with atomized rhizoma bletillae polysaccharide-chitosan composite hydrogel and a preparation method and a purpose thereof, and belongs to the field of biomedical materials. The composite hydrogel is obtained in a way that after probiotics, atomized rhizoma bletillae polysaccharide solution and chitosan solution are mixed, an obtained mixture is subjectedto cross-linking reaction, and the atomized rhizoma bletillae polysaccharide is obtained in a way that rhizoma bletillae polysaccharide is oxidized by an oxidizing agent. The composite hydrogel has good mechanical properties and biocompatibility and does not have toxic or side effects for the liver and kidney, the three-dimensional porous net structure of the composite hydrogel is favorable for absorbing the redundant seepage of a wound to prevent the wound from being infected, and a good moist environment is provided for a wound surface healing process; meanwhile, the pH value of the hydrogel is faintly acid so as to be more favorable for protection and healing of the wound; and in addition, the composite hydrogel has excellent antibacterial performance and has an extremely good wound surface repairing effect. The atomized rhizoma bletillae polysaccharide-chitosan composite hydrogel combined with lactobacillus plantarum has a good application prospect on an aspect of clinical wound surface repairing, and is expected to be developed into a potential wound surface dressing.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a probiotic-combined oxidized white and polysaccharide-chitosan composite hydrogel, a preparation method and application thereof. Background technique [0002] Wound infections generally result in prolonged wound healing times and the potential for chronic, non-healing wounds, exposing patients to significant health risks. Currently, wound care dressings emphasize the use of antibiotics or Ag + and other antimicrobial compounds added to wound dressings. Unfortunately, its development is hindered by problems such as bacterial resistance and cytotoxicity. Therefore, alternative therapies that do not rely on commonly used antimicrobial agents are becoming increasingly important in wound care. [0003] Probiotics are microorganisms that have positive effects on the host. In recent years, the medical use of probiotics and prebiotics has increased rapidly, confirming ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/24C08J3/075C08B37/00C08L5/08C08L5/00
CPCA61L26/008A61L26/0095A61L26/0085A61L26/0066A61L26/0057C08J3/246C08J3/075C08B37/0003C08B37/00A61L2300/412A61L2300/404C08J2305/08C08J2405/00C08J2305/00C08J2405/08C08L5/08C08L5/00
Inventor 曾锐瞿燕杨玲
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES
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