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Platelet aggregation rate detection method and detection device

A technology of platelet aggregation and detection method, applied in the new field of platelet function detection, can solve the problems of instrument volume size distinction, inaccurate detection of aggregation rate, etc., and achieve the effects of increasing accuracy, simple operation and low cost

Pending Publication Date: 2021-03-19
滁州瑞谷生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there is little difference in volume between small aggregates and individual platelets, it is difficult for the instrument to distinguish them by size, thus resulting in inaccurate detection of aggregation rate

Method used

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  • Platelet aggregation rate detection method and detection device
  • Platelet aggregation rate detection method and detection device
  • Platelet aggregation rate detection method and detection device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Device embodiment

[0044] Such as figure 1 As shown, a platelet detection device of the present invention comprises:

[0045] Triaxial loading arm, combined with figure 2 As shown, there is a sample loading arm 1 on it, which can be freely moved along the three directions of X-axis 2, Y-axis 3, and Z-axis 4 above the overall detection device; the moving mode of each axis can adopt the existing technology, such as Electric telescopic arm, electric slider, rack and pinion, cylinder, etc. are all available.

[0046] Below the three-axis sample loading arm, there are counting pool 14, Tip nozzle position 5, Tip nozzle probe 7, nozzle remover 16, waste box 6, rotating detection position 10, sample position 9, reagent position 8, A magnetic bead position 12; a sample needle 15 and a detection unit 13 are provided on one side of the triaxial sample loading arm.

[0047] There are 5 suction nozzle positions, and multiple Tip suction nozzle slots are set in the box to arra...

Embodiment 2

[0059] Specific steps for instrument testing:

[0060] 1) The instrument moves to the top of the Tip suction nozzle position 5 through the XYZ three-axis sample loading arm, and the Z-axis 4 moves downward to obtain the disposable Tip head (or suction nozzle) placed inside the Tip suction nozzle position, and the sample loading arm Run to the tip nozzle probe 7, and check whether the tip nozzle is taken correctly.

[0061] 2) The sample loading arm moves above the sample position 9, and draws 0.6 ml of blood sample (whole blood sample is used in this embodiment) in the sample.

[0062] 3) The sample loading arm moves above the rotating detection position 10, and injects the blood sample into the disposable detection cup on the detection position.

[0063] 4) The sample loading arm moves to the suction nozzle remover 16 again, and the Tip suction nozzle is removed and placed in the waste box 6 .

[0064] 5) The sample needle runs above the rotating detection position 10 throu...

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Abstract

The invention discloses a platelet aggregation rate detection method which comprises the steps: activating and aggregating platelets, crosslinking the platelets with magnetic beads coated with fibrinogen on the surfaces, aggregating the crosslinked activated platelets to a certain specific area by using magnetic force, and measuring the concentration of unactivated platelets in samples in other areas; and calculating the platelet aggregation rate according to the initial concentration of the platelets and the concentration of the unactivated platelets. By adopting the method provided by the invention, the influence on platelet aggregation in the detection process and the influence on quantity measurement caused by different aggregation conditions of platelets are avoided, and the detectionaccuracy is effectively improved.

Description

technical field [0001] The invention belongs to the field of blood testing, and in particular relates to a new platelet function testing method. Background technique [0002] The platelet function analyzer is mainly used clinically to assist the diagnosis and treatment of thrombotic diseases through the detection of platelet aggregation function. According to WHO data: In 2015, about 15 million people died of ischemic heart disease and stroke worldwide. In the past 15 years, thrombotic diseases have been the number one killer of human health. Studies have shown that the level of platelet function is closely related to the occurrence and development of thrombotic diseases: for patients with vascular injury / stenosis, the higher the platelet function, the higher the probability of thrombosis, and vice versa, the higher the probability of bleeding. As an effective predictive method for the occurrence / recurrence of thrombotic diseases, platelet function testing has been confirm...

Claims

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Application Information

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IPC IPC(8): G01N33/96
CPCG01N33/96
Inventor 曹宁张国英叶良凯
Owner 滁州瑞谷生物技术有限公司
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