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Liquid ophthalmic agent which is suppressed in decrease of dibutylhydroxytoluene content

A technology of dibutylhydroxytoluene and liquid preparations, which is applied in the directions of liquid delivery, emulsion delivery, and medical preparations of inactive ingredients, etc., can solve the problem of not being made into ophthalmic liquid preparation formulations, etc., and achieve the effect of inhibiting content reduction.

Pending Publication Date: 2021-03-19
SENJU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A personal care composition suitable for skin is known as a composition containing xanthan gum and dibutylhydroxytoluene (Patent Document 3: US / 2010 / 0150971), but there is no ophthalmic liquid formulation

Method used

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  • Liquid ophthalmic agent which is suppressed in decrease of dibutylhydroxytoluene content
  • Liquid ophthalmic agent which is suppressed in decrease of dibutylhydroxytoluene content
  • Liquid ophthalmic agent which is suppressed in decrease of dibutylhydroxytoluene content

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Experimental program
Comparison scheme
Effect test

reference example 1

[0100] The quantitative sample of Reference Example 1 was gelled and could not be measured. After storing each test sample at 60° C. for 2 weeks and 4 weeks, the respective BHT contents were measured using HPLC. The ratio of the BHT content of the 60°C stored product to the BHT content of the 4°C stored product in the measurement results of each test sample is shown as the residual rate (%).

[0101] [Table 8]

[0102]

[0103] All the thickeners have the effect of suppressing the reduction of the BHT content, but especially the suppression effect of the reduction of the BHT content of xanthan gum, gelatin, and carrageenan is high.

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Abstract

The content of dibutylhydroxytoluene which is blended as an antioxidant in an ophthalmic liquid agent decreases in the ophthalmic liquid agent due to the volatility, adsorbability and degradability thereof. The present invention provides an ophthalmic liquid agent which is suppressed in decrease of the dibutylhydroxytoluene content by blending dibutylhydroxytoluene together with at least one thickening agent that is selected from the group consisting of xanthane gum, gelatin and carrageenan.

Description

technical field [0001] The present invention relates to an ophthalmic liquid preparation containing a thickener and dibutylhydroxytoluene, which suppresses a decrease in the content of dibutylhydroxytoluene (BHT) in the ophthalmic liquid preparation. Background technique [0002] Dibutylhydroxytoluene is known as a representative compound of fat-soluble antioxidants, and it is compounded in ophthalmic aqueous liquid preparations such as eye drops for the purpose of stabilizing active ingredients (Patent Document 1: JP-A-07-304670). [0003] On the other hand, polysaccharides such as xanthan gum can promote viscosity when mixed with water, and are used as thickeners. Xanthan gum is used in food and cosmetics, and its safety has been confirmed. In addition, in pharmaceuticals, natural polymers such as xanthan gum are blended in compositions as thickeners and stabilizers, and the main purpose is to stabilize active ingredients in these compositions (Patent Document 2: Japanese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/10A61K9/08A61K9/10A61K47/14A61K47/26A61K47/36A61K47/42A61K47/44A61P27/02
CPCA61K47/42A61K47/44A61K47/10A61K9/10A61K47/26A61K47/14A61K47/36A61P27/02A61K9/08
Inventor 松久敬一
Owner SENJU PHARMA CO LTD
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