Microneedle for piezoelectric single-sperm injection and production method for microneedle
A technology of micromanipulation needle and manufacturing method, which is applied in the field of piezoelectric single sperm injection micromanipulation needle and its manufacture, can solve the problems of damage to oocytes, thorn deviation, and tearing of egg plasma membrane, etc. Improve the conception rate, high production efficiency and convenient operation
Inactive Publication Date: 2021-03-26
东蕴医疗科技(上海)有限公司
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Problems solved by technology
Therefore, there will be the following disadvantages in the single sperm microinjection: 1. The membrane breaking force is too large, and the ooplasmic membrane of the oocyte will have tearing wounds, and the ooplasmic membrane is difficult to restore to its original state; 2. If the breaking force is too small, the elasticity of the oocyte will cause the single sperm injection needle to be biased. At this time, repeated operations will damage the oocyte, which will seriously affect the fertilization rate
These factors greatly restrict the conception rate of current single sperm microinjection (ICSI) technology
Method used
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[0034] In order to enable those skilled in the art to better understand the technical solutions in the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described The embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.
[0035] Such as figure 1 As shown, the specific embodiment of the present invention is a micromanipulation needle for piezoelectric single sperm injection, which is a tubular structure of hollow glass, including: a main body section 1, an extension section 2 and a function section 3, the extension section 2 includes a bottom end 11, a t...
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Abstract
The invention provides a microneedle for piezoelectric single-sperm injection. The microneedle is of a tubular structure of hollow glass and comprises a main body section, an extension section and a functional section; the extension section comprises a bottom end, a top end and an extension, the top end of the extension section is connected with a bent part of the functional section, and the bottom end of the extension section is connected with the main body section; and the functional section comprises the bent part and a long tube part. A production method comprises the steps of heating a central position of a glass capillary with a heating device so as to soften the glass capillary, then, carrying out stretching, and carrying out operations such as needle breaking and bending on the tipend of the stretched glass capillary, thereby obtaining the microneedle capable of being applied to the piezoelectric single-sperm injection. By using the device provided by the invention, injury toan oocyte of an oocyte cytoplasm single sperm microinjection (ICSI) technology can be reduced, and the conception rate is increased; and the microneedle for the piezoelectric single-sperm injection inline with clinical use can be produced by using the method provided by the invention; and the operation is convenient, and the production efficiency is high.
Description
technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a micromanipulation needle for piezoelectric single sperm injection and a manufacturing method thereof. Background technique [0002] Oocyte Cytoplasmic Sperm Injection (ICSI) technology is a new type of artificial assisted reproductive technology developed in the late 1980s. It uses a micromanipulator to directly inject a sperm into the oocyte cytoplasm Inside, the process of combining sperm and oocyte to complete fertilization. The ICSI technique bypasses all the processes of normal fertilization, such as the acrosome reaction, the passage of sperm through the zona pellucida and the ooplasmic membrane. Because ICSI technology has relatively high fertilization rate, low fertilization rate of polyspermy, eliminates the barrier effect of zona pellucida and ooplasmic membrane on sperm entering oocyte, and can overcome the influence of sperm concentration, shape and vital...
Claims
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IPC IPC(8): C12M1/24C12M1/00C03B23/11C03B23/09C03B23/06
CPCC12M21/06C12M23/16C03B23/11C03B23/09C03B23/06
Inventor 胡彦新尹航夏旭升尹丽雯
Owner 东蕴医疗科技(上海)有限公司