Fused gene, fused protein, recombinant vector and general DC vaccine of coronavirus and preparation methods for fused gene, fused protein, recombinant vector and general DC vaccine of coronavirus

A technology of fusing gene and coronavirus, applied in the field of universal DC vaccine and its preparation, can solve the problems such as universal DC cell vaccine targeting coronavirus that has not been reported
CN112592928AActive Publication Date: 2021-04-02BEIJING DCTY BIOTECH CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING DCTY BIOTECH CO LTD
Publication Date
2021-04-02

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Abstract

The invention provides a fused gene, fused protein, recombinant vector and general DC vaccine of coronavirus and application of the fused gene, fused protein, recombinant vector and general DC vaccineof the coronavirus and belongs to the technical field of preparation of viral vaccines. The fused gene comprises a gene for encoding a protein N of a COVID-19 virus and a gene for encoding a RBD monomer, dimer or trimer protein of the COVID-19 virus. A general DC cell vaccine of the coronavirus is obtained through expressing the fused gene in an antigen presentation cell line. The general DC vaccine can be used for effectively activating T cells. According to records of embodiments, the general DC vaccine provided by the invention can be used for effectively activating specific antibodies ofmacaca fascicularis to the proteins N and RBD of the COVID-19 virus.
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Description

technical field

[0001] The invention belongs to the technical field of virus vaccine preparation, and particularly relates to fusion genes, fusion proteins, recombinant vectors, universal DC vaccines of three coronaviruses and preparation methods thereof. Background technique

[0002] The coronavirus belongs to the genus Coronaviridae of the family Coronaviridae in the systematic classification. The human diseases caused by coronavirus are mainly respiratory system infections. At present, the types of coronavirus vaccines in the prior art include inactivated coronavirus vaccines, coronavirus spike protein vaccines, and adenovirus vector vaccines.

[0003] However, there is currently no report on a universal DC cell vaccine targeting coronaviruses in the prior art. SUMMARY OF THE INVENTION

[0004] In view of this, the object of the present invention is to provide a kind of fusion gene of coronavirus, fusion protein, recombinant vector, universal DC vaccine and preparation...

Claims

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