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Application of dronedarone to preparation of medicine for preventing and treating colitis

A technology for dronedarone and colitis, applied in the field of medicine

Active Publication Date: 2021-04-09
THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the application of dronedarone in the treatment of colitis

Method used

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  • Application of dronedarone to preparation of medicine for preventing and treating colitis
  • Application of dronedarone to preparation of medicine for preventing and treating colitis
  • Application of dronedarone to preparation of medicine for preventing and treating colitis

Examples

Experimental program
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Effect test

Embodiment 1

[0024]Example 1 Study on the therapeutic effect of Netherona against sulfate sodium sulfate sodium salt (DSS) induced ulcerative colitis mice

[0025]1. Modeling method of DSS induced ulcerative colitis mouse (DSS modeling mice)

[0026]C57 / 6J male mice were randomly divided into 4 groups of 32 weighing 20-25 g, 8, respectively, in control group, DSS modeling group (DSS), compound decinated Daron Group (DSS + DRO) and Positive control of the o'salaharazine group (DSS + OLZ). The control group mouse normal drinking water, DSS model group, compound decinaurine group and positive control drug O'Harbazine groups were drinking 2.5% DSS special drinking water for 7 days, and replaced special drinking water on the next day, induced mice Ulcerative colitis model.

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PUM

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to application of dronedarone to preparation of a medicine for preventing and treating colitis. In oder to mine a new compound for treating ulcerative colitis, the invention discovers by research of the treatment effect of the compound dronedarone on DSS-induced ulcerative colitis mice that the dronedarone has the treatment effect on the ulcerative colitis of the DSS-induced mice , and is expected to be applied to prevention and treatment of the ulcerative colitis.

Description

Technical field[0001]The present invention belongs to the field of medical technology, and in particular to the application of Nargo Darong in the preparation of colitis.Background technique[0002]DRONEDARONE (DRO) is a new anti-diamond drug developed by Sanofi Avante, France. It won the US FDA approved by the US FDA in July 2009. It is used for atrial fibrillation and atrial. (AF / AFL) Anti-diamonds. It is an iodine-free benzofuran derivative, the structure and pharmacological characteristics are similar to amiodarone, and there is no obvious thyroid inhibitory effect and thyroid hormone inhibition, and there is less reaction to a new generation of antiarrhythmia drugs.[0003]Inflammatory Bowel Disease, IBD) is a idiopathic intestinal inflammatory disease, including ulcerative colitis, ulcerative colitis (UC) and Crohn's Disease. CD). Ulcerative colitis is a coastal mucosa layer and a continuous inflammation of submucosa under mucosa, spreading to full colon. Epidemiological data sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P1/00A61P1/04
CPCA61K31/343A61P1/00A61P1/04
Inventor 刘焕亮张瀞丹张敏陈骏雄李伟倩王子涵杨湘玲
Owner THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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