Hypoallergenic soothing epidermis anesthesia cream as well as preparation method and application thereof

A soothing and creamy technology, used in anesthetics, ointment delivery, pharmaceutical formulations, etc., to solve problems such as redness and swelling reactions, skin allergic reactions, etc.

Active Publication Date: 2021-04-23
山东光普医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But lidocaine can also cause allergic skin reactions, especially in patients with sensitive skin
When the patient does not tolerate lidocaine, it can cause a more severe redness and swelling reaction

Method used

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Examples

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preparation example Construction

[0029] In one embodiment of the present disclosure, a preparation method of hypoallergenic soothing epidermal anesthesia cream, comprising: mixing a solution containing an anesthetic and a solution containing a soothing agent, adjusting the pH of the mixed solution to neutral, adding Emulsifier, thickener, adjust pH to neutral.

[0030] In one embodiment of the present disclosure, a preparation method of hypoallergenic soothing epidermal anesthesia cream, the specific preparation method includes:

[0031] Weigh lidocaine and prilocaine, add pure water and stir until dissolved;

[0032] Weigh 4-tert-butylcyclohexanol and dipotassium glycyrrhizinate, add purified water and stir until dissolved;

[0033] Mix the above two solutions, stir evenly, and adjust the pH to neutral with alkali;

[0034] Finally, polyoxyethylene fatty acid ester and hydroxypolymethylene are added, and the pH is adjusted to neutral after stirring evenly.

[0035] Further, the pH is 8-10, preferably, the...

Embodiment 1

[0039] A hypoallergenic soothing epidermal anesthesia cream, the formula and preparation method are as follows: every 1000ml cream contains:

[0040] Element content Lidocaine 10g Prilocaine 10g 4-tert-Butylcyclohexanol 1.5g Dipotassium glycyrrhizinate 1.5g polyoxyethylene fatty acid ester 12g Hydroxypolymethylene 12g water About 900ml-950ml NaOH 1-2g

[0041] Preparation:

[0042] 1. Weigh the lidocaine and prilocaine in the prescribed amount, add purified water to dissolve, and stir until completely dissolved.

[0043] 2. Weigh 4-tert-butylcyclohexanol and dipotassium glycyrrhizinate in the prescribed amount, add purified water to dissolve, and stir until completely dissolved.

[0044] 3. Mix the above two solutions, stir evenly, and adjust the pH to 8.

[0045] 4. Add the formula amount of polyoxyethylene fatty acid ester and stir until dissolved.

[0046] 5. Add the formula amount of hydroxypolymethylene, s...

Embodiment 2

[0049] A hypoallergenic soothing epidermal anesthesia cream, the formula and preparation method are as follows: every 1000ml cream contains:

[0050] Element content Lidocaine 15g Prilocaine 15g 4-tert-Butylcyclohexanol 2g Dipotassium glycyrrhizinate 2g polyoxyethylene fatty acid ester 10g Hydroxypolymethylene 10g water About 900ml-950ml NaOH 1-3g

[0051] Preparation:

[0052] 1. Weigh the lidocaine and prilocaine in the prescribed amount, add purified water to dissolve, and stir until completely dissolved.

[0053] 2. Weigh 4-tert-butylcyclohexanol and dipotassium glycyrrhizinate in the prescribed amount, add purified water to dissolve, and stir until completely dissolved.

[0054] 3. Mix the above two solutions, stir evenly, and adjust the pH to 8.5.

[0055] 4. Add the formula amount of polyoxyethylene fatty acid ester and stir until dissolved.

[0056] 5. Add the formula amount of hydroxypolymethylene, stir ...

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PUM

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Abstract

The invention provides a hypoallergenic soothing epidermis anesthesia cream as well as a preparation method and application thereof. The cream comprises the following components of 5-20 g of an anesthetic, 0.5-2 g of a soothing agent, 8-15 g of an emulsifier, 8-15 g of a thickener and the balance of 900-950 ml of purified water. By adding specific soothing components, the sensitization risk caused by lidocaine and prilocaine can be greatly reduced, and particularly, the cream can also effectively relieve postoperative adverse reactions.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a low-sensitivity soothing epidermal anesthesia cream and its preparation method and application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Cream containing lidocaine can be used for local skin anesthesia. In recent years, many manufacturers have made lidocaine into ointment. Lidocaine ointment is very convenient. Using this ointment to penetrate local mucous membranes and skin, Acts on superficial nerve endings to produce analgesic effect. Lidocaine ointment can also be applied to the items that need to be introduced, and after it acts on the mucous...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/167A61K47/14A61K47/54A61K47/32A61P23/02
Inventor 钟德志
Owner 山东光普医疗科技有限公司
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