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Biomarker for diagnosing Alzheimer's disease and progress of Alzheimer's disease and application of biomarker

A kind of Alzheimer's disease, material technology, applied in the field of biomarkers for the diagnosis of Alzheimer's disease and Alzheimer's disease progression, capable of solving complex etiology and pathogenesis, incompletely clear, without delaying disease progression, etc. question

Inactive Publication Date: 2021-04-23
THE SECOND HOSPITAL OF SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

AD has a complex etiology and pathogenesis that is not fully understood
In terms of clinical treatment, there is a lack of effective radical cures, and there is no effective drug to delay the progression of the disease

Method used

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  • Biomarker for diagnosing Alzheimer's disease and progress of Alzheimer's disease and application of biomarker
  • Biomarker for diagnosing Alzheimer's disease and progress of Alzheimer's disease and application of biomarker
  • Biomarker for diagnosing Alzheimer's disease and progress of Alzheimer's disease and application of biomarker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Patient and control group selection:

[0019] Collect 30 cases of AD patients (including 6 with MCI, 7 with mild AD, 6 with moderate AD, and 11 with severe AD) and 30 age-sex-matched elderly with normal cognitive function. Fasting peripheral blood.

[0020] 1) Inclusion criteria: ① Meet the diagnostic criteria of MCI and AD in the "2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment"; ② Sign the informed consent.

[0021] 2) Exclusion criteria: ①age≦60 years old; ②suffering from other nervous system diseases or other systemic diseases; ③HAMD≧15 points, patients with obvious depressive symptoms or Hachinski ischemia score≧7 points, patients with vascular dementia; ④ The patient or family members do not cooperate.

[0022] 3) Cognitive function assessment uses MMSE, MoCA, and CDR scales.

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Abstract

The invention belongs to the technical field of biological diagnosis of diseases, and relates to a biomarker for diagnosing Alzheimer's disease and progress of Alzheimer's disease and application of the biomarker. According to the present invention, by detecting the TOM70 mRNA level in the whole blood of the AD patient and the old people with the normal gender and age matching cognitive function, the decrease of the TOM70 mRNA level in the whole blood of the AD patient is found, and the decrease and the AD disease progress are in the negative correlation; mouse hippocampal tissue TOM70 mRNA and protein level detection is carried out, it is found that the APP / PS1 transgenic mouse hippocampal tissue TOM70 level is lowered, and it is proved that the expression level of TOM70 in AD is lowered. The invention provides a novel mRNA biomarker TOM70, and a whole blood TOM70 mRNA and / or TOM70 protein level which can be used for diagnosing the Alzheimer's disease and a marker for the progress of the Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of disease biological diagnosis, and relates to a biomarker for diagnosing Alzheimer's disease and Alzheimer's disease progress and its application. Background technique [0002] Alzheimer's disease (Alzheimer's Disease, AD) is the most common type of dementia in the elderly, with progressive cognitive impairment as the main clinical manifestation. In 2018, there were about 50 million dementia patients worldwide, of which AD patients accounted for 50%-75%; my country is the country with the largest aging population in the world, and the number of dementia patients in 2018 has reached 9.5 million. According to statistics, the global cost of dementia in 2015 was as high as 957.56 billion U.S. dollars, and it will reach 9.12 trillion U.S. dollars in 2050. The above data show that dementia has posed a huge threat to global public health and social health care, and solving the problem of dementia is a severe cha...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883A61K45/00A61P25/28
CPCC12Q1/6883A61K45/00A61P25/28C12Q2600/158
Inventor 徐琳琳何启明武静吴昊曹曦
Owner THE SECOND HOSPITAL OF SHANDONG UNIV
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