Lipophenolic flavonoid derivatives useful to reduce carbonyl and oxidative stresses (COS)
A compound and alkyl technology, applied in the fields of flavonoid derivatives, prevention and/or treatment of retinopathy and neurodegenerative diseases, can solve the problems that the main toxicity mechanism cannot be reduced or cannot be effectively reduced
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment Construction
[0237] 1- Synthesis of Fatty Phenol Derivatives
[0238] a) Materials and methods
[0239] All solvents were commercially sourced anhydrous reagents. All chemicals and reagents were obtained from commercial sources and used without purification unless otherwise stated. Commercial quercetin, rutin or (+)-catechin were dried under vacuum at 100°C for 48 hours before use. The reaction was monitored by TLC on plates precoated with silica gel 60 (Merck). The reaction components were visualized using a 254nm UV lamp, stained with an acidic p-anisaldehyde solution, and then heated gently. The synthesized compounds were purified by column chromatography on 40–63 mm silica gel. Melting points (Mp) were determined on a Stuart capillary apparatus without correction. NMR spectra were performed on a Bruker spectrometer at 300 or 500 MHz ( 1 H) and 75 or 126MHz ( 13 C) Recorded. Chemical shifts are reported in parts per million (ppm, δ) relative to the residual deuterated solvent ...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More