Polysaccharide-based tissue bonding medical adhesive and application thereof

A technology of polysaccharides and tissues, applied in the fields of application, medical science, surgical adhesives, etc., can solve the problems of fast degradation time in vivo, poor water resistance, poor gap filling performance of porous and rough surfaces, etc.

Active Publication Date: 2021-05-18
稳得希林(杭州)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the defects of poor impact resistance, low viscosity, poor interstitial performance to porous and rough surfaces, fast degradation time in vivo, no heat resistance, and poor water resistance, this adhesive has been restricted in its application in medicine to a certain extent. limitations

Method used

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  • Polysaccharide-based tissue bonding medical adhesive and application thereof
  • Polysaccharide-based tissue bonding medical adhesive and application thereof
  • Polysaccharide-based tissue bonding medical adhesive and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]Preparation of Polyscharous Base Adhesive Medicine: The 2 g of N-hydroxy succinimide modified glucan (structural formula:Where M = 5 to 2000, N = 1 to 1800, the substitution is 90%) and 0.5 g of branched polyethylene imine is dissolved in 50 ml of deionized water, and stirred for 6 hours. Conventional purification, dry, ground, obtained powder-shaped polysaccharide-bonded medical adhesive gum 1,

Embodiment 2

[0029]Preparation of Polyscharous Base Adhesive Medicine: 2g Oxidized Oxide Powder (Structure Form ":Among them, M = 20 to 1000, N = 1 to 900, and the substitution is 70%) to obtain a powder-shaped polysaccharide-bonded medical adhesive 2 after mixing with 0.8 g of a dicamine hydrochloride powder.

Embodiment 3

[0031]Preparation of Polyscharous Base Adhesive Medicine: Polyethylene glycol modified Prouran (structured:Where M = 15 to 4000, N = 1 to 3600, the substitution is 5%) and 0.6 g of alpha-cyclodextrinolysis in 60 ml of deionized water, and stirred for 3 hours. It is conventionally purified, dried, and grinded to obtain a powder-shaped polysaccharide-bonded medical adhesive glue 3.

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PUM

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Abstract

The invention discloses a polysaccharide-based tissue bonding medical adhesive and application thereof. The polysaccharide-based tissue bonding medical adhesive is composed of a polysaccharide derivative and a compound with at least two reaction functional groups, wherein the polysaccharide derivative and the compound with at least two reaction functional groups generate a bonding effect through one or more of a physical effect and a chemical reaction; and the polysaccharide derivative is polysaccharide after functional group substitution. The polysaccharide-based tissue bonding medical adhesive can bear relatively large tension, has relatively short tissue bonding time and relatively high tissue stripping force compared with a cyanoacrylic acid medical adhesive, can realize rapid bonding and sealing of wounds, has strong adhesion with tissues after being applied, is not easy to strip, can be suitable for stretched wounds, and can realize effective closing.

Description

Technical field[0001]The present invention belongs to the field of biomedical materials, involving polysaccharide-bonded medical adhesive and its application thereof.Background technique[0002]Medical glue refers to a formulation, material or substance that adheres to surface or causes surface between medical applications, mainly used for local bonding and repair of organs or tissues, replacing conventional suture; or tissue, blood vessels The combination and positioning of the sealing and other technologies. In contrast, the use of traditional methods such as stitching with staples can effectively shorten the operation time, significantly reduce the pain of patient. In tissue bonding, bonding generally involves several aspects: 1. Adhesion between internal activity of life tissue; 2. The adhesion between the organism and the medical glue; 3. Medical glue Adhesion. An important part of life organization is protein, so the interaction between medical glue and proteins is the main role...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/001A61L24/043C08L5/08C08L5/04C08L5/12C08L3/02C08L1/02C08L5/00C08L5/02C08L5/16
Inventor 徐福建李杨
Owner 稳得希林(杭州)生物科技有限公司
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