Multi-mode biological particle concentrator
A technology of biological particles and concentrators, applied in the preparation of test samples, etc., can solve the problem of fewer instruments, achieve low production costs, reasonable structural design, and improve the concentration function
Active Publication Date: 2021-06-04
SOUTHEAST UNIV
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Problems solved by technology
For the detection of cell suspension, the concentration of the sample has a great influence on the ability and efficiency of the detection. Even the detection species also needs to increase the concentration to make the detection more efficient. However, there are very few instruments for sample concentration. Therefore, it is necessary to develop a Multi-mode cell concentration instrument for rapid concentration of samples
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[0037]The specific embodiments of the present invention will be described below in conjunction with the accompanying drawings.
[0038] like figure 1 As shown, the multi-mode biological particle concentrator of this embodiment includes a display screen 1, a liquid circuit control chip 2, a concentration chip 3, a liquid storage tank interface module 4, an air circuit control module 5, a lithium battery 6 and a circuit control board 7 .
[0039] like figure 2 As shown, the liquid circuit control chip 2 is composed of a seven-layer stacked structure, including an upper cover plate 21, an upper air channel layer 22, an upper film layer 23, a liquid channel layer 24, a lower film layer 25, and a lower air channel layer. Runner layer 26, lower cover layer 27;
[0040] The liquid circuit control chip 2 is integrated with a number of stop valves, fluid passages corresponding to the stop valves, and fluid interfaces corresponding to the fluid passages. The liquid circuit control c...
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The invention discloses a multi-mode biological particle concentrator which comprises a liquid path control chip on which a plurality of stop valves, fluid passages correspondingly communicated with the stop valves and fluid interfaces correspondingly communicated with the fluid passages are integrated, wherein each stop valve comprises a liquid path flow channel and a gas path flow channel; a cell sample liquid inlet, wherein a cell concentrated liquid outlet and a plurality of waste liquid outlets which are correspondingly connected with the liquid inlet and the liquid outlet of the stop valve are formed in the concentration chip; a liquid storage tank module, which is provided with a sample liquid tank, a waste liquid tank and a collection liquid tank which are respectively connected with the concentration chip through a pipeline via the liquid path control chip to form a liquid path circulation system; and a gas circuit control module which comprises a gas source, a plurality of electromagnetic valves and a connecting pipeline, and is used for controlling the on-off of each stop valve and providing stable gas pressure for each liquid tank of the liquid storage tank module; herein, the liquid path circulation system has the functions of a primary concentration mode, a waste liquid recovery mode and a re-concentration mode, so that rapid, automatic and high-magnification concentration of various cell samples is realized.
Description
technical field [0001] The invention relates to the technical field of microfluidic cell screening, and relates to a multi-mode biological particle concentrator. Background technique [0002] In the research of modern medicine and biological related subjects, the concentration of biological cell suspension has become an indispensable process. The concentration of the target sample is usually to concentrate the biological particles (such as biological cells, bacteria and algal cells) from a large suspension by reducing the volume of the background liquid. The concentration of the sample is an important prerequisite for successful downstream detection or in vitro culture. . In the current biomedical system, the reduction of background liquid is achieved by centrifugation or membrane-based filtration technology. Centrifugal separation is to settle the target particle components to the bottom of the centrifuge tube under the action of centrifugal force generated by ultra-high-...
Claims
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Login to View More IPC IPC(8): G01N1/40
CPCG01N1/40
Inventor 项楠任慧倪中华
Owner SOUTHEAST UNIV