Electromagnetically excited magneto-thermoacoustic and ultrasonic dual-mode magnetic nanoparticle imaging method and device

Abstract

Electromagnetically excited magneto-thermoacoustic and ultrasonic dual-mode magnetic nanoparticle imaging method and device. A magnetic field is generated by a coil to excite magnetic nanoparticles located in biological tissues and biological tissues, and the magnetic field excitation acts on the magnetic nanoparticles, so that the magnetic nanoparticles have A certain amount of magnetization energy induces thermal expansion and excites thermoacoustic signals, that is, magnetothermal acoustic signals; the ultrasonic transducers distributed around the magnetic nanoparticles and biological tissues receive the acoustic signals. At the same time, the magnetic field or current excitation acts on the ultrasonic transducer. On the energy device, the acoustic wave signal is induced to propagate to the biological tissue and magnetic nanoparticles, and then received by the ultrasonic transducer after reflection. The ultrasonic transducer receives both thermoacoustic signals and ultrasonic signals. The thermoacoustic and ultrasonic signals include magnetic nanoparticles and biological Organize the information, and finally achieve image reconstruction. The coupled imaging device applying the method of the present invention is composed of an excitation source, a detection system, an electromagnetic-ultrasonic coupling conversion, and a dual-mode imaging unit.

Description

technical field [0001] The invention relates to an electromagnetically excited magneto-thermoacoustic and ultrasonic dual-mode magnetic nanoparticle imaging method and device. Background technique [0002] Malignant tumors are one of the major diseases that threaten human health. Tumors are mostly in the middle and late stages when diagnosed by routine clinical diagnostic techniques. The detection of cancer without nodules is of great significance for improving the prognosis of patients. There is an urgent need to develop imaging techniques that can be used for early diagnosis of cancer and its metastasis. [0003] From a pathological point of view, in general, early cancer changes, metastases and lesions after treatment, which are difficult to detect by traditional imaging examinations, have undergone significant changes at the gene and cellular levels. With the development and application of various types of targeted nanodiagnostic agents, molecular imaging technology tha...

AI Technical Summary

Problems solved by technology

For magnetic nanoparticles, the electromagnetic and ultrasonic coupling imaging method provides a new means for molecular imaging technology. At present, the electromagnetic and ultrasonic coupling imaging methods for magnetic nanoparticles are mostly in the feasibility verification stage, and most of them focus on the excitation method. In terms of the research on the characteristics of the excited ultrasound signal, there is no in-depth research on imaging methods for accurate diagnosis

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