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Method for preparing oral liquid prepared by fermenting raspberry leaves

A technology of raspberry leaves and oral liquid, which is applied to the methods of using microorganisms, medical formulas, and dispersion liquid delivery, etc., can solve the problems of complicated process, insufficient utilization of medicinal decoction liquid, and large energy consumption, so as to achieve the protection of metabolic utilization , to ensure that the prescription and efficacy remain unchanged, and the effect of full release and utilization

Pending Publication Date: 2021-06-11
INST OF MICROBIOLOGY JIANGXI ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies in the prior art, the present invention provides a method for preparing oral liquid prepared by fermenting raspberry leaves, which solves the complicated production process of traditional oral liquid preparations, including washing and immersing two or more tradition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of lactic acid bacteria strains induced by step-by-step training of raspberry leaves:

[0030] (1) Preparation of raspberry leaf culture solution: take 60g of raspberry dried leaves, wash with water, soak in hot water and soak for hair, homogenize together and add water to make up to 600ml;

[0031] (2) Prepare raspberry leaf-MRS mixed culture solution in different proportions: ①0:1 culture solution: only take 100ml of MRS culture solution, ②1:3 culture solution: mix 25ml of raspberry leaf culture solution and 75ml of MRS culture solution, ③1: 1 Culture solution: mix 50ml of raspberry leaf culture solution with 50ml of MRS culture solution, ④2:1 culture solution: mix 60ml of raspberry leaf culture solution with 30ml of MRS culture solution, ⑤3:1 culture solution: take raspberry leaf culture solution Mix 75ml with 25ml of MRS culture solution, ⑥4:1 culture solution: take 80ml of raspberry leaf culture solution and mix with 20ml of MRS culture solution,⑦1:0 cu...

Embodiment 2

[0034] (1) 6000g raspberry dry leaves are cleaned of impurities, washed with water, soaked in hot water and soaked in hair, and then add food grade 12gMgSO 4 ·7H 2 O. 300g of sucrose and 120g of corn steep liquor powder, mixed and homogenized, poured into a 100L fermenter and added water to 52L, stirred evenly, heated to 121°C for 20 minutes, cooled to 37°C, and steam sterilized The condensed water, the culture medium is controlled at about 60L, the above process is also the process of accelerated decoction of raspberry leaves.

[0035] (2) to the nutrient solution that step (1) obtains, insert fermentation process bacterial seed liquid 5L, viable count is 3 * 10 8 CFU / mL, stirring at 120r / min for 3min, static fermentation at 37°C for 36h, intermittent stirring for 3 times during fermentation, sampling and microscopic examination of the fermentation broth until pH = 4.5, the end of fermentation, 80-mesh filtration to obtain 56L of fermentation broth filtrate about.

[0036]...

Embodiment 3

[0039] (1) 6000g raspberry dried leaves are cleaned of impurities, washed with water, soaked in hot water and soaked in hair, and then add food-grade 12gMgSO 4 ·7H 2 O. 300g of sucrose and 120g of corn steep liquor powder, mixed and homogenized, poured into a 100L fermenter and added water to 52L, stirred evenly, heated to 121°C for 20 minutes, cooled to 37°C, and steam sterilized The condensed water, the culture medium is controlled at about 60L, the above process is also the process of accelerated decoction of raspberry leaves.

[0040] (2) insert 3.3L of fermented bacterial seed liquid to the nutrient solution that step (1) obtains, and the number of live bacteria is 3 * 10 8 CFU / mL, stirring at 120r / min for 1min, static fermentation at 37°C for 33h, intermittent stirring for 3 times during fermentation, sampling and microscopic examination of the fermentation broth until pH = 4.0, the end of fermentation, 120-mesh filtration to obtain 56L of fermentation broth filtrate a...

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Abstract

The invention discloses a method for preparing oral liquid by fermenting raspberry leaves, which comprises the following steps: taking dried raspberry leaves as a basis, taking magnesium sulfate, cane sugar and corn steep liquor powder as a culture solution, and fermenting and processing the culture solution by using lactic acid bacteria subjected to special domestication induction. According to the special acclimatization-induced lactic acid bacteria, raspberry leaves are crushed and homogenized to prepare a medicinal material culture solution, the proportion of the medicinal material culture solution in an MRS culture solution is gradually increased, and a lactic acid bacteria strain which has tolerance to the raspberry leaves and can be used as a self-growth culture medium is acclimatized and induced. In the production process, the processes of repeated decoction, distillation and concentration are omitted, the fermentation liquor filtrate is the oral liquid, bioactive products and flavor substances obtained after lactic acid bacteria fermentation are added, the taste is improved, the content of the effective component total flavonoids in the oral liquid is increased, and the oral liquid has multiple health-care functions and natural flavor.

Description

technical field [0001] The invention relates to the technical field of plant processing, in particular to a preparation method of raspberry leaf fermented processed oral liquid. Background technique [0002] Oral liquid is based on traditional Chinese medicine decoction, extracting the active ingredients in the medicine, adding additives such as flavoring agents and antibacterial agents, and making a sterile or semi-sterile product according to the injection ampoule filling and sealing process. Oral liquid formulation, therefore also known as oral ampoules. Its production generally adopts some mature and traditional preparation techniques, especially the health oral liquid based on water-soluble traditional Chinese medicine decoction. [0003] The traditional oral liquid production process is to wash two or more kinds of traditional Chinese medicinal materials, soak them in water, decoct them three times, combine the decoctions, heat and concentrate them, and then go throug...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61K9/08A61K47/36A61K47/26A61K47/02A61P39/00C12N1/36A23L33/105A61K127/00
CPCA61K36/73A61K9/0095A61K47/36A61K47/26A61K47/02A61P39/00C12N1/36A23L33/105A61K2236/19
Inventor 郑国华涂远曦黄虹涂祖新
Owner INST OF MICROBIOLOGY JIANGXI ACADEMY OF SCI
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