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Preparation method of spica schizonepetae volatile oil clathrate compound, application thereof in preparation of children cold spray and preparation method of spray

A technology of nepeta ear and volatile oil, which is applied in the directions of aerosol delivery, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc.

Inactive Publication Date: 2014-07-16
南京海思创新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention will solve the shortcomings of low inclusion rate, long preparation time, poor repeatability and incapable of industrial production in the inclusion compound of nepeta panicle volatile oil-cyclodextrin in the prior art
The present invention will also solve the following technical problems in the prior art: it is necessary to improve the water solubility of the volatile oil of nepeta panicle through inclusion, and to avoid the use of ethanol; complex

Method used

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  • Preparation method of spica schizonepetae volatile oil clathrate compound, application thereof in preparation of children cold spray and preparation method of spray
  • Preparation method of spica schizonepetae volatile oil clathrate compound, application thereof in preparation of children cold spray and preparation method of spray
  • Preparation method of spica schizonepetae volatile oil clathrate compound, application thereof in preparation of children cold spray and preparation method of spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0212] Example 1, a preparation method of nepeta panicle volatile oil clathrate, the steps are as follows: pre-mix HP-β-cyclodextrin and water according to the water weight volume ratio of 1:3 (g:ml), at 40°C Dissolve at low temperature and keep constant temperature; according to the weight volume ratio of HP-β-cyclodextrin: nepeta volatile oil 4:1 (g:ml), slowly add nepeta volatile oil to the above premix for premixing Uniform for 5 minutes; after mixing, put it into a colloid mill and grind it for 15 minutes, control the speed of the colloid mill at 1500r / min, refrigerate at 0°C for 12 hours, suction filter, blow dry at 40°C for 3 hours, crush, pass through a 60-mesh sieve, That is, the cyclodextrin inclusion compound of nepeta panicle volatile oil was obtained.

Embodiment 2

[0213] Example 2, a preparation method of nepeta panicle volatile oil-HP-β-cyclodextrin inclusion compound, the steps are as follows: HP-β-cyclodextrin and water are mixed according to the water weight volume ratio of 1:5 (g:ml ) to be pre-mixed, dissolved at 60°C, and kept at a constant temperature; according to the weight-volume ratio of HP-β-cyclodextrin:Nepeta volatile oil of 8:1 (g:ml), the Schizonepeta volatile oil was slowly added to In the above premixed solution, premix evenly for 10 minutes; after mixing, put it into a colloid mill and grind it for 45 minutes, control the speed of the colloid mill at 3000r / min, refrigerate at 4°C for 24h, suction filter, vacuum dry at 60°C for 6h, and grind crushed, and passed through a 80-mesh sieve to obtain the cyclodextrin inclusion compound of the nepeta panicle volatile oil.

Embodiment 3

[0214] Example 3, a preparation method of nepeta panicle volatile oil-HP-β-cyclodextrin inclusion compound, the steps are as follows: mix HP-β-cyclodextrin and water according to the water weight volume ratio of 1:4 (g:ml ) for pre-mixing, dissolved at 50°C, and kept at a constant temperature; according to the weight-volume ratio of HP-β-cyclodextrin: nepeta volatile oil 6:1 (g:ml), slowly add nepeta volatile oil to In the above premixed solution, premix evenly for 10 minutes; after mixing, add it to a colloid mill for grinding for 30 minutes, control the colloid mill speed to 2500r / min, refrigerate at 4°C for 12h, suction filter, vacuum dry at 40°C for 6h, and grind crushed, and passed through a 60-mesh sieve to obtain the cyclodextrin inclusion compound of the nepeta panicle volatile oil.

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Abstract

The invention provides a preparation method of a spica schizonepetae volatile oil clathrate compound, an application thereof in preparation of a children cold spray and a preparation method of the spray. The preparation method of the spica schizonepetae volatile oil clathrate compound comprises the following steps: premixing HP-beta-cyclodextrin with water, slowly adding spica schizonepetae volatile oil into the premixed solution, uniformly mixing, adding the mixture into a colloidal mill or a ball mill for grinding, refrigerating, function filtering, drying, crushing and sieving to obtain a spica schizonepetae volatile oil-HP-beta-cyclodextrin clathrate compound, wherein the weight to volume ratio of the HP-beta-cyclodextrin to water is (1:3)-(1:5), dissolving the spica schizonepetae volatile oil-HP-beta-cyclodextrin clathrate compound at a temperature of 40-60 DEG C, wherein the weight to volume ratio of the HP-beta-cyclodextrin to the spica schizonepetae volatile oil is (4:1)-(8:1), and slowly adding the spica schizonepetae volatile oil into the aqueous solution droplet by droplet. The preparation method provided by the invention is simple to operate, simple in equipment and capable of achieving continuous mass production. The water solubility of the obtained clathrate compound is increased, the safety problem of children caused by ethanol is avoided, the preparation is stable and the bioavailability is high.

Description

technical field [0001] The invention relates to a preparation method of nepeta panicle volatile oil-HP-β-cyclodextrin inclusion compound; application of the nepeta panicle volatile oil-HP-β-cyclodextrin inclusion compound in preparing children's cold spray and the preparation method of this oral spray for treating colds in children. Background technique [0002] Pediatric drug use is a topic of common concern all over the world, and the safety of children's drug use has received increasing attention in recent years. In the existing market, there are many medicines for treating and preventing colds, but most of them are for adults, and there are few exclusive medicines for children, which leads to serious irrational use of medicines for children and seriously affects the safety of children's medicines. Pediatricians often use antibacterial drugs, antipyretic analgesics, etc. when treating children with colds, which have large side effects and are prone to drug resistance; a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/538A61K9/12A61K47/48A61P11/00
Inventor 储益平管伦兴朱华荣
Owner 南京海思创新生物科技有限公司
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