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Multi-parameter analysis and characterization method of cavitation classification during low-intensity pulsed ultrasonic cavitation synergistic drug release

A pulsed ultrasound, low-intensity technology, applied in ultrasonic therapy, treatment and other directions, can solve the problems of limited bandwidth, lack of multi-component characterization methods of cavitation signals, and inability to characterize the release of cavitation synergistic drugs by ultrasound, avoiding the need for The effect of power-frequency interference and high-sensitivity multi-parameter PCM detection and evaluation

Active Publication Date: 2022-08-05
XI AN JIAOTONG UNIV
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Problems solved by technology

However, single-array elements or array PCD and PCM transducers with a single center frequency have limited bandwidth and are difficult to cover a wider frequency band; at the same time, they are also interfered by power-frequency aliasing of ultrasonic therapy transducers
Moreover, there is currently a lack of multi-component characterization methods for cavitation signals, and it is impossible to effectively characterize the cavitation field for ultrasonic cavitation-enhanced drug release.
Especially for low-intensity pulsed ultrasonic therapy transducers, the sensitivity of the existing cavitation detection methods is lower due to the low emission energy and the complex environment of the tissue boundary membrane, resulting in the aliasing of the bandwidth and power frequency of the above-mentioned PCD and PCM. The limitations of multi-component characterization of interference and cavitation signals are more prominent

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  • Multi-parameter analysis and characterization method of cavitation classification during low-intensity pulsed ultrasonic cavitation synergistic drug release
  • Multi-parameter analysis and characterization method of cavitation classification during low-intensity pulsed ultrasonic cavitation synergistic drug release
  • Multi-parameter analysis and characterization method of cavitation classification during low-intensity pulsed ultrasonic cavitation synergistic drug release

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Embodiment Construction

[0038] The present invention will be described in further detail below with reference to the accompanying drawings and embodiments. The embodiments are only used to explain the present invention, but not to limit the protection scope of the present invention.

[0039] The present invention proposes a high-sensitivity multi-parameter analysis and characterization method for cavitation classification when using low-intensity pulsed ultrasonic cavitation synergistic drug release, comprising the following steps:

[0040] Step 1: The low-intensity pulsed ultrasonic therapy transducer excites micron-scale enveloped microbubbles to generate cavitation, thereby enhancing the efficiency of the drug penetrating the tissue boundary membrane.

[0041]Step 2: Use dual-frequency passive cavitation detection to perform passive cavitation distribution tracing analysis on the cavitation field when the low-intensity pulsed ultrasonic cavitation synergistic drug is released.

[0042] Step 3: Th...

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Abstract

The invention discloses a multi-parameter analysis and characterization method for cavitation classification when a low-intensity pulse ultrasonic cavitation synergistic drug is released. High and low dual-frequency ultrasonic probes are used to detect the passive cavitation signal, and the dual-frequency passive cavitation detection signal is located and traced. The cavitation component is characterized in time and space, and finally the temporal cavitation total curve of the steady-state cavitation total and the transient cavitation total is extracted, and the multi-parameter extraction of the steady-state and transient cavitation classification is carried out. The invention realizes the highly sensitive multi-parameter analysis and characterization of the cavitation effect of the low-intensity pulsed ultrasound, and can provide multi-angle evaluation for the release of the cavitation synergistic drug of the low-intensity pulsed ultrasound.

Description

technical field [0001] The invention belongs to the field of ultrasonic cavitation detection, in particular to a multi-parameter analysis and characterization method for cavitation classification when a low-intensity pulse ultrasonic cavitation synergistic drug is released. Background technique [0002] Ultrasonic cavitation is a complex hydrodynamic phenomenon peculiar to the propagation of ultrasound in a liquid medium. There are two kinds of cavitation processes, one is the oscillation of the microbubble and the steady-state cavitation in the growth process, and the other is the compression of the microbubble and the transient cavitation in the collapse process. Steady-state cavitation produces stable, uniform acoustic microflows with small diameters, and the shear force is sufficient to produce biological effects. Under transient cavitation, extreme physical phenomena such as high temperature, high pressure, shock wave and micro-jet will be generated. The micro-jets an...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N7/00
CPCA61N7/00A61N2007/0039
Inventor 王弟亚王巧万明习张蕾徐鹏飞
Owner XI AN JIAOTONG UNIV
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