Plasmon resonance (PR) system and instrument, digital microfluidic (DMF) cartridge, and methods of using localized surface plasmon resonance (LSPR) for analysis of analytes
An instrument, droplet technology, applied in plasmon resonance (PR) systems and instruments, digital microfluidics (DMF) boxes, and in the field of analyte analysis using localized surface plasmon resonance (LSPR), capable of addressing unsuitable Problems with detection of target analytes, low sensitivity and throughput, and expensive immunoassays
Pending Publication Date: 2021-06-11
NICOYA LIFESCI INC
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Problems solved by technology
However, these techniques show low sensitivity and throughput, thus making them unsuitable for detection of target analytes at very low concentrations
Specifically, SPR technology has certain disadvantages
For example, immunoassays using SPR technology can be expensive, may require complex microfluidic systems and high-precision optics, may require complex assays, and are a niche technology with few specialists
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[0072] The presently disclosed subject matter now will be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the presently disclosed subject matter are shown. Like numbers refer to like elements throughout. The presently disclosed subject matter may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will satisfy applicable legal requirements. Indeed, many modifications and other embodiments of the present disclosed subject matter set forth herein will come to mind to one skilled in the art to which the disclosed subject matter pertains having the benefit of the teachings presented in the foregoing descriptions and the associated drawings. Therefore, it is to be understood that the presently disclosed subject matter is not to be limited to the particular embodiments disclosed and that mod...
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A plasmon resonance (PR) system and instrument, digital microfluidic (DMF) cartridge, and methods of using localized surface plasmon resonance (LSPR) and droplet operations for analysis of analytes is disclosed. For example, the PR system is provided that may include the DMF cartridge that may support both fixed LSPR sensing capability and in-solution LSPR sensing capability for analysis of analytes. The DMF cartridge may include an electrode arrangement for performing droplet operations, wherein the droplet operations can be used for performing fixed LSPR sensing operations and in-solution LSPR sensing operations. Further, methods of using droplet operations in the DMF cartridge to perform fixed LSPR sensing operations and / or in-solution LSPR sensing operations are provided.
Description
[0001] Cross References to Related Applications [0002] The currently disclosed subject matter is related to, and claims rights to, a submission entitled: "Plasmon resonance (PR) systems and instruments, digital microfluidics (DMF) cassettes, and U.S. Provisional Patent Application 62 / 727,934, filed May 29, 2019, entitled "Plasmon Resonance (PR) Systems and Instruments, Digital Microfluidic (DMF) Cassettes, and Applications Using Partial Surface US Provisional Patent Application 62 / 854,103, the priority of which is incorporated herein by reference in its entirety. technical field [0003] The presently disclosed subject matter generally relates to the detection of molecules, such as DNA, proteins, drugs, and the like, and more specifically, to plasmon resonance (PR) systems and instruments, digital microfluidic (DMF) cassettes, and the use of Localized surface plasmon resonance (localized surface plasmonresonance, LSPR) and droplet operations (droplet operations) to analyze ...
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IPC IPC(8): G01N21/77B82Y15/00G01N1/00
CPCG01N21/554G01N2021/258B01L3/502792B01L2400/0427B01L3/502715B01L2400/043B82Y30/00G01N21/553G01N33/5438
Inventor R.德诺姆A.苏达桑
Owner NICOYA LIFESCI INC