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Methods for lowering blood sugar with a gliflozin sodium-glucose cotransporter 2 inhibitor pharmaceutical composition

A pharmaceutical composition and a technique for gilliflozin sodium are applied in the field of lowering blood sugar by using the gliflozin sodium (gliflozin sodium)-glucose co-transporter 2 inhibitor pharmaceutical composition, and can solve problems such as unachieved results and the like

Pending Publication Date: 2021-06-11
ASTRAZENCA UK LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when aimed at simulating 10mg When a phase 3 "real use" trial of OTC use of (atorvastatin calcium) failed to meet its primary goal, it was not attempted in 2014 because patients followed instructions to check their LDL Unsatisfactory results in cholesterol (LDL-C) levels and taking appropriate action based on their test results after checking their LDL-C levels

Method used

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  • Methods for lowering blood sugar with a gliflozin sodium-glucose cotransporter 2 inhibitor pharmaceutical composition
  • Methods for lowering blood sugar with a gliflozin sodium-glucose cotransporter 2 inhibitor pharmaceutical composition
  • Methods for lowering blood sugar with a gliflozin sodium-glucose cotransporter 2 inhibitor pharmaceutical composition

Examples

Experimental program
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Effect test

example 1

[0375] Example 1: A computer system configured to qualify an individual for over-the-counter delivery of a dapagliflozin pharmaceutical composition for treating diabetes (eg, by lowering blood sugar). The computer system includes instructions for conducting a survey of an individual. Using a survey to obtain one or more of the following outcomes: whether the individual is pregnant, breastfeeding, or planning to become pregnant; the individual's type 1 diabetes status; the individual's ketoacidosis status; the individual's renal disease status; the individual's age; the individual's blood sugar level ; whether the individual has liver problems; whether the individual has ever had urinary problems; the individual's surgical status; the individual's dietary status; whether the individual has ever had pancreatic problems; the individual's alcohol consumption status; whether the individual is using diabetes medications; Bladder Cancer.

[0376] The computer system runs the finding...

example 2

[0385] Example 2: A computer system configured to qualify an individual for over-the-counter delivery of a canagliflozin pharmaceutical composition for the treatment of diabetes (eg, by lowering blood sugar). The computer system includes instructions for conducting a survey of an individual. Using a survey to obtain one or more of the following outcomes: whether the individual is pregnant, breastfeeding, or planning to become pregnant; the individual's type 1 diabetes status; the individual's ketoacidosis status; the individual's renal disease status; the individual's age; the individual's blood sugar level ; whether the individual has liver problems; whether the individual has ever had urinary problems; the individual's surgical status; the individual's dietary status; whether the individual has ever had pancreatic problems; the individual's alcohol consumption status; whether the individual is using diabetes medications; The subject's history of resection; the subject's hist...

example 3

[0395] Example 3: A computer system configured to qualify an individual for over-the-counter delivery of an epagliflozin pharmaceutical composition for the treatment of diabetes (eg, by lowering blood sugar). The computer system includes instructions for conducting a survey of an individual. Using a survey to obtain one or more of the following outcomes: whether the individual is pregnant, breastfeeding, or planning to become pregnant; the individual's type 1 diabetes status; the individual's ketoacidosis status; the individual's renal disease status; the individual's age; the individual's blood sugar level ; whether the individual has liver problems; whether the individual has ever had urinary problems; the individual's surgical status; the individual's dietary status; whether the individual has ever had pancreatic problems; the individual's alcohol consumption status; whether the individual is using diabetes medications; The subject's history of leg neuropathy; and the subje...

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PUM

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Abstract

A method is provided for lowering blood sugar in a subject in need thereof by administering a gliflozin Sodium-Glucose Cotransport 2 inhibitor pharmaceutical composition to a subject qualified for over-the-counter access to the gliflozin Sodium- Glucose Cotransport 2 inhibitor pharmaceutical composition. In some embodiments, the gliflozin Sodium-Glucose Cotransport 2 inhibitor pharmaceutical composition includes empagliflozin, canagliflozin, and ertugliflozin. In some embodiments, the gliflozin Sodium- Glucose Cotransport 2 inhibitor pharmaceutical composition includes (2S,3R,4R,5S,6R)-2- [4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol or a pharmaceutically acceptable salt thereof.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 62 / 685,202, filed June 14, 2018, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure generally relates to methods for lowering blood sugar, such as thereby treating type 2 diabetes and / or maintaining subdiabetic blood sugar levels, by administering over-the-counter gliflozin Sodium-glucose to an individual in need thereof cotransport Agent 2 inhibitor pharmaceutical composition, wherein the individual is eligible to obtain the composition over-the-counter. Background technique [0004] Worldwide, diabetes is a leading cause of death and increased healthcare costs. NCD Risk Factor Collaboration, The Lancet, 387:1513-1530 (2016). Since 1980, the number of people with diabetes worldwide has almost tripled. Ditto. As of 2015, about 12% of all adults in the United States have diabetes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H20/10G16H10/20G16H50/20A61K31/351A61K31/381A61P3/10
CPCG16H20/10G16H10/20G16H50/20A61K31/70A61K31/7048A61K31/7056A61K31/7034G16H10/40G16H10/60G16H70/40G16H20/13
Inventor R·P·普莱伯尔斯基J·菲罗尔
Owner ASTRAZENCA UK LTD