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Preparation method and application of Pickering emulsion by utilizing prolamin loaded eucommia ulmoides chlorogenic acid

A Pickering emulsion, Eucommia chlorogenic acid technology, applied in the directions of skin care preparation, application, emulsion delivery, etc., can solve the problems of application limitation, delamination phenomenon, instability of Pickering emulsion, etc., and achieve strong steric stability , uniform distribution, the effect of improving bioavailability

Pending Publication Date: 2021-06-15
INST OF ANALYSIS GUANGDONG ACAD OF SCI (CHINA NAT ANALYTICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Pickering emulsion prepared by a single gliadin is unstable and presents a layered phenomenon, so its application in complex food systems is also greatly limited.

Method used

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  • Preparation method and application of Pickering emulsion by utilizing prolamin loaded eucommia ulmoides chlorogenic acid
  • Preparation method and application of Pickering emulsion by utilizing prolamin loaded eucommia ulmoides chlorogenic acid

Examples

Experimental program
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Embodiment 1

[0022] Example 1: Preparation of zein-chlorogenic acid composite particles by anti-solvent method.

[0023] Accurately weigh 2.5 g of zein and disperse it into 100 mL of 70% (v / v) ethanol solution, and fully stir for 2 hours at room temperature to ensure that the protein is fully dissolved. Weigh 100 mg of chlorogenic acid and fully dissolve it in 70% ethanol solution, and set the volume to 50 mL to obtain a chlorogenic acid solution with a concentration of 2.0 mg / mL. Take an appropriate amount of zein solution, add chlorogenic acid solution in proportion and mix evenly, the mass ratio of zein to chlorogenic acid is 10:1, 20:1, 30:1, 40:1, 50:1, Stirring at 1500 rpm at 25°C for 1.0 h, adding pectin (pectin) solution (1.0%) with a pH of 4.0, with a volume ratio of 3:1 to zein, adjusting the pH of the solution to 5.0 by 1.0 mol / L NaOH, Stirring was continued for 1.0 h, concentrated under reduced pressure at 40° C. to remove ethanol, centrifuged at 4000 rpm for 15 min to remove ...

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Abstract

The invention discloses a preparation method of Pickering emulsion by utilizing prolamin loaded eucommia ulmoides chlorogenic acid. The unique solubility and self-assembly characteristic of prolamin are utilized, composite nanoparticles of prolamin loaded chlorogenic acid are prepared by adopting an anti-solvent method, and the Pickering emulsion is further prepared. The preparation method is simple in operation, small in the dosage of an emulsifier, low in cost, and environment-friendly; the prepared Pickering emulsion is uniform in particle size distribution, free of surfactants, low in toxicity and obvious in biological activity; alcohol-soluble nano-particles form a compact interface layer on an oil-water interface, so that the Pickering emulsion is high in stability and biocompatibility and is degradable, and polysaccharide-based particles are high in spatial stability and can resist flocculation and coagulation phenomena, so that the stability of the Pickering emulsion can be further improved, the solubility and stability of chlorogenic acid can be obviously improved, and the bioavailability of chlorogenic acid can be improved.

Description

Technical field: [0001] The invention relates to the technical fields of food, medicine and cosmetics, in particular to a preparation method and application of eucommia chlorogenic acid Pickering emulsion loaded with gliadin. Background technique: [0002] Eucommia chlorogenic acid (Chlorogenic acid, CA) is a depsipolic acid produced by caffeic acid and quinic acid, and is a phenylpropanoid compound produced by plants through the shikimic acid pathway during aerobic respiration. Biological activity, but due to its poor solubility and low stability, it greatly affects its bioavailability. At present, the bioavailability of Eucommia chlorogenic acid can be improved by constructing a safe and stable embedding system through emulsification technology. The traditionally prepared emulsion is an unstable system due to the large oil-water interface area. Generally, small molecular surfactants or high molecular polymers are added as emulsifiers or other small molecular weight stabil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/216A61K47/42A61K47/38A61K47/36A61K47/44A23L33/105A61K8/64A61K8/37A61K8/73A61K8/06A61Q19/00A61K36/46
CPCA61K9/107A61K31/216A61K47/42A61K47/38A61K47/36A61K47/44A23L33/105A61K8/645A61K8/375A61K8/73A61K8/736A61K8/731A61K8/733A61K8/737A61K8/06A61Q19/00A61K36/46A23V2002/00A61K2800/10A61K2800/52A61K2800/413A23V2200/30A23V2250/028A23V2250/548
Inventor 王志宏彭密军黄韬杨秋玲
Owner INST OF ANALYSIS GUANGDONG ACAD OF SCI (CHINA NAT ANALYTICAL
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