Gentiana macrophylla cataplasm and preparation method thereof

A Gentiana and solvent technology, applied in the field of medicine, can solve the problems of cataplasms not forming a scale, and achieve the effects of low cost, large drug loading, and simple operation

Pending Publication Date: 2021-06-15
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to the immature production technology of cataplasms, the development and application of new products of catapl

Method used

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  • Gentiana macrophylla cataplasm and preparation method thereof
  • Gentiana macrophylla cataplasm and preparation method thereof
  • Gentiana macrophylla cataplasm and preparation method thereof

Examples

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Example Embodiment

[0056] One embodiment of the present invention also proposes a preparation method of Gentiana catarrh, comprising the following steps:

[0057] 1) Add the cross-linking agent and transdermal accelerator to the moisturizer in turn, mix, add skeleton material, filler, disperse and stir evenly, and obtain phase A;

[0058] 2) Dissolve the cross-linking regulator in an appropriate amount of water to obtain phase B; gradually add an appropriate amount of water to the thickener, stir and dissolve it fully, and then add the refined Gentiana to obtain phase C;

[0059] 3) Add phase B and phase C to phase A, mix, stir in a water bath at 40-50°C, and coat it on the non-woven backing material while it is hot, mature at a constant temperature of 40-60°C for 2-4 hours, take it out and cool to After 20-35°C, cover with film, let stand for 8-12 hours, cut and seal to obtain Gentiana cataplasma.

[0060] The preparation method of the Gentiana cataplasm according to the present invention dire...

Example Embodiment

[0070] Example 1 A preparation method of Gentiana cataplasma, comprising the steps of:

[0071] 1. Preparation of refined Gentiana chinensis

[0072] a) Weigh a sufficient amount of Gentiana chinensis medicinal material (dried rhizome), coarsely crush it, heat and reflux extraction with ethanol with a volume fraction of 65% for three times, each time for 2 hours, filter, combine the filtrates, concentrate and dry to obtain a crude extract;

[0073] b) add water to the crude extract to make a crude extract of Gentiana fenugreek containing 0.08g of crude drug per milliliter, take the above crude extract, and apply HPD300 macroporous resin for purification, the column diameter-to-height ratio is 1:6, and the loading volume is 8BV. 3BV of ultrapure water was used to remove impurities in the aqueous solution, and then 4BV of 30% ethanol was used for elution, and the eluent was combined, and the eluent was recovered from ethanol, concentrated and dried to obtain a thick cream or dr...

Example Embodiment

[0079] Example 2 A preparation method of Gentiana cataplasma, comprising the steps of:

[0080] 1. Preparation of refined Gentiana chinensis

[0081] a) Weigh a sufficient amount of Gentiana chinensis medicinal material, coarsely crush it, heat and reflux with 70% ethanol to extract three times, each time for 3 hours, filter, combine the filtrates, concentrate and dry to obtain the crude extract;

[0082] b) Add water to the crude extract to make a crude extract of Gentiana fenugreek containing 0.12g of crude drug per milliliter. Take the above crude extract and put it on AB-8 macroporous resin for purification. The column diameter-to-height ratio is 1:5, and the loading volume is 6BV, eluted with 2BV of ultra-pure water to remove impurities in the aqueous solution, then eluted with 5BV of 30% ethanol, combined the eluent, recovered the ethanol from the eluent, concentrated and dried to obtain a thick paste or dry paste powder, and obtained the refined product of Gentiana ch...

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Abstract

The invention provides a gentiana macrophylla cataplasm and a preparation method thereof, and particularly relates to the technical field of medicines. The cataplasm is prepared from the following raw materials in parts by weight: 1 to 5 parts of radix gentianae macrophyllae refined substance, 3 to 5 parts of framework material, 1 to 2 parts of filler, 0.3 to 0.8 part of tackifier, 20 to 40 parts of humectant, 0.2 to 0.5 part of cross-linking agent, 0.02 to 0.05 part of cross-linking regulator, 1 to 3 parts of transdermal enhancer and the balance of ultrapure water, and the total parts of all the raw materials are 100 parts. Wherein the gentiana macrophylla refined substance is prepared from the following components in parts by weight: 1 to 2 parts of swertiamarin; 7 to 15 parts of 6'-O-beta-D-glucosyl gentiopicroside, and 50 to 80 parts of gentiopicroside. The gentiana macrophylla cataplasm provided by the invention has the advantages of obvious anti-inflammatory effect, strong adhesive force, good permeability, no pain during stripping, and good biocompatibility and affinity to skin.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a Gentiana cataplasma and a preparation method thereof. Background technique [0002] Gentiana is a perennial herb of the Gentianae Gentiana Gentiana group. The Chinese Pharmacopoeia 2020 edition stipulates that the dried roots of four types of Gentiana (Gentida small, Gentiana large, Gentiana twisted, and Gentiana thick stems) can be used as medicine. The dry root of Gentiana quinquefolium has the effects of dispelling rheumatism, clearing damp-heat, and relieving arthralgia. It can be used for arthralgia due to rheumatism, spasms of muscles and arteries, sore joints, hot flashes in the evening, and malnutrition fever in children. Gentiana chinensis is an essential medicinal material for treating rheumatic paralysis and arthrosis in traditional Chinese medicine. Modern pharmacological studies have shown that iridoids in Gentiana are the main active ingredients. [0003] At pr...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K36/515A61K31/7048A61K47/32A61P29/00A61K125/00
CPCA61K9/7023A61K36/515A61K31/7048A61K47/32A61P29/00A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 陈光刘欢赵欢孟世安
Owner BEIJING UNIV OF CHEM TECH
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