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Anti-RNA virus drug target activity and application of compound solid goldenrod spray dry powder

The technology of a spray and a compound recipe is applied in the application field of compound solid goldenrod spray extract dry powder, the preparation of novel coronavirus pneumonia and antiviral drugs, and can solve problems such as no effective vaccines

Active Publication Date: 2022-08-09
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no effective vaccine or specific treatment for this virus

Method used

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  • Anti-RNA virus drug target activity and application of compound solid goldenrod spray dry powder
  • Anti-RNA virus drug target activity and application of compound solid goldenrod spray dry powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1: It has been verified by experiments that the dry powder of compound solid goldenrod spray extract, at 1 mg / mL, has an inhibition rate of 55.6% for CathepsinL protease; the inhibition rate for HIV-1 protease is IC 50 =0.38mg / mL, which can be used to prepare the treatment of new coronary pneumonia and antiviral drugs.

Embodiment 2

[0054] Embodiment 2: get compound solid goldenrod spray extract dry powder, make granules, capsules, tablets, injections, oral liquids, soft capsules, drop pills and other acceptable dosage forms.

Embodiment 3

[0055] Embodiment 3: get compound solid goldenrod spray extract dry powder, add other antiviral raw materials to compound, make granules, capsules, tablets, injections, oral liquids, soft capsules, drop pills and other medicaments acceptable dosage form.

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PUM

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Abstract

The present invention discloses a new application of compound solidarum spray extract dry powder in pharmacy. The present invention finds that compound solidarum spray extract dry powder at 1 mg / mL can inhibit the new coronavirus drug target Cathepsin L protease by 55.6%. ; the inhibition rate of HIV protease is IC 50 =0.38mg / mL can be used alone or in combination with other drugs for the prevention and treatment of new coronavirus pneumonia drugs and antiviral drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of compound solid goldenrod spray extract dry powder in the preparation of novel coronavirus pneumonia and antiviral medicines. technical background [0002] The new coronavirus (SARS-CoV-2) is a single-stranded RNA positive-strand enveloped beta-coronavirus. After invading the human body through droplets, contact, and feces, it rapidly attacks multiple organs such as the lungs, heart, kidneys, and intestines. Multiple organ failure, eventually leading to death. There is currently no effective vaccine or specific treatment for the virus. At present, there have been more than 3 million cases of new coronary pneumonia in the world, and the new coronavirus infection has become one of the most deadly infectious diseases in the world, seriously endangering human health. [0003] The replication cycle of the new coronavirus (SARS-CoV-2) includes the stages of invasio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/634A61K9/14A61P31/14A61P31/18
CPCA61K36/28A61K36/355A61K36/12A61K36/634A61K36/534A61K36/538A61K9/0073A61K9/14A61P31/14A61P31/18A61K2300/00Y02A50/30
Inventor 危英李星周英夏文马超美杨欣
Owner 贵州中医药大学
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