Metal organic framework nano-drug, preparation method thereof and application of metal organic framework nano-drug in anti-tumor treatment
A metal-organic framework and nano-drug technology, applied in the field of biomedicine, can solve the problem of low hydrogen solubility, and achieve the effect of inhibiting drug resistance and metastasis, and precise treatment.
Pending Publication Date: 2021-06-29
SHENZHEN UNIV
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Problems solved by technology
However, due to the low solubility of hydrogen and the random diffusion in the body, it is usually difficult for hydrogen molecules to effectively reach and accumulate in deep lesion tissues by directly inhaling hydrogen, injecting or drinking hydrogen-rich water, so the construction has high biological safety. , and the degradable hydrogen nanomedicine that can precisely release hydrogen is a big challenge
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[0044]In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them.
[0045] It should be noted that, those without specific conditions indicated in the examples were carried out according to conventional conditions or conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased from the market. In addition, the meaning of "and / or" appearing in the whole text includes three parallel schemes, taking "A and / or B" as an example, including scheme A, scheme B, or schemes that both A and B satisfy. In addition, the technical solutions of various embodiments can be combined with each ot...
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Abstract
The invention discloses a metal organic framework nano-drug, a preparation method thereof and application of the metal organic framework nano-drug in anti-tumor treatment, and relates to the technical fields of biology, nano-materials and medicine and pharmacology. The metal organic framework nano-drug comprises a metal organic framework nano-material and a chemotherapeutic drug, wherein the metal organic framework nano-material reacts with acid to release hydrogen; and the chemotherapeutic drug is impregnated and supported on the metal organic framework nano-material through a solution. The metal organic framework nano-drug provided by the invention can simultaneously release hydrogen and the chemotherapeutic drug in a subacid tumor environment, the released hydrogen can effectively inhibit drug resistance and metastasis of tumor cells, the toxicity of the chemotherapeutic drug is reduced, the treatment effect is improved, and precise treatment of tumors is realized.
Description
technical field [0001] The invention relates to the technical field of biomedicine, in particular to a metal organic framework nano-medicine, its preparation method and its application in anti-tumor treatment. Background technique [0002] With the change of human living environment, the morbidity and mortality of tumors have increased significantly. According to the 2020 global cancer morbidity and mortality estimates by international research institutions, there will be 19.3 million new cancer cases and 10 million deaths worldwide. And 90% of cancer patients' deaths are directly or indirectly related to tumor recurrence, drug resistance and metastasis. The current clinical treatment of cancer is mainly chemotherapy, but the multidrug resistance of chemotherapy and the easy metastasis of tumor cells have seriously affected the clinical treatment effect of cancer. [0003] As an emerging treatment, gas therapy is widely favored by medical researchers because of its ability ...
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Login to View More IPC IPC(8): A61K47/54A61K31/409A61K31/555A61K45/00C08G83/00A61P35/00A61P35/04B82Y5/00B82Y30/00B82Y40/00
CPCA61K47/546A61K45/00A61K31/409A61K31/555C08G83/008B82Y5/00B82Y30/00B82Y40/00A61P35/00A61P35/04A61K2300/00
Inventor 何前军杨武利姚先先王英帅
Owner SHENZHEN UNIV