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Metallic silver-n-heterocyclic carbene polymer, preparation method and application thereof

A technology of heterocyclic carbene and metal silver, which can be applied in silver organic compounds, organic chemical methods, drug combinations, etc., and can solve problems such as adverse side effects

Active Publication Date: 2022-06-24
HUBEI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although a large number of platinum-based metal compound drugs have been proven to be very effective against a variety of tumors, they also have some disadvantages, such as adverse side effects in the treatment of cancer patients

Method used

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  • Metallic silver-n-heterocyclic carbene polymer, preparation method and application thereof
  • Metallic silver-n-heterocyclic carbene polymer, preparation method and application thereof
  • Metallic silver-n-heterocyclic carbene polymer, preparation method and application thereof

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Embodiment Construction

[0030] In order to facilitate understanding of the present invention, the present invention will be described more fully hereinafter with reference to the related drawings. Possible embodiments of the invention are shown in the accompanying drawings. However, the present invention may be embodied in many different forms and is not limited to the embodiments that have been described herein with reference to the accompanying drawings. The embodiments described with reference to the accompanying drawings are exemplary and are used to make the understanding of the disclosure of the present invention more thorough and complete, and should not be construed as limiting the present invention. Furthermore, if detailed descriptions of known technologies are not necessary to illustrate the features of the invention, such technical details may be omitted.

[0031] It will be understood by those skilled in the relevant art that unless otherwise defined, all terms (including technical and ...

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Abstract

The invention relates to a metallic silver-N-heterocyclic carbene polymer, comprising C-Ag-C bonds and N-Ag-N bonds, wherein the C-Ag-C bonds and N-Ag-N bonds alternately form a One-dimensional linear polymer, the molecular formula of the one-dimensional linear polymer is C 17 h 13 AgN 3 f 6 p. The preparation method of metallic silver-N-heterocyclic carbene polymer provided by the present invention uses benzimidazole and 8-iodoquinoline as raw materials, and after coupling reaction, quaternization reaction and carbene metallization reaction, metallic silver is synthesized ‑N‑heterocyclic carbene polymer, the metal silver ‑N‑heterocyclic carbene polymer can kill tumor cells at a lower concentration, but has no effect on the growth and survival of normal breast cells, and can be applied to the preparation of anti-breast cancer new therapeutic drugs.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a metal silver-N-heterocyclic carbene polymer, a preparation method and an application thereof. Background technique [0002] Breast cancer is one of the malignant tumors with the fastest growing incidence in recent years, seriously endangering women's health and life safety. Chemotherapy is the most widely used method for the treatment of breast cancer, but traditional anti-breast cancer drugs have many thorny problems. At the same time, it also has different degrees of toxic and side effects on various types of cells that reproduce normally in the body, and it is easy to cause damage to the immune system, making it resistant to some breast cancer patients. Therefore, it is necessary to develop effective anti-tumor drugs for breast cancer. treatment is of great practical significance. [0003] Since people discovered that cisplatin has anticancer activity, the application an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F1/10A61P35/00
CPCC07F1/10A61P35/00C07B2200/13
Inventor 金传明杜晓刚罗文琦帅海娟陈雨
Owner HUBEI NORMAL UNIV