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Patterned hydrogel particle preparation method and microfluidic device

A microfluidic device and hydrogel technology, applied in gel preparation, chemical instruments and methods, colloid chemistry, etc., can solve problems such as difficult to flexibly design internal compartments of particles

Active Publication Date: 2021-07-06
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These techniques can be used to prepare patterned particles, but these techniques are usually difficult to flexibly design the structure of the internal compartment of the particle, such as the asymmetric structure distribution inside the particle

Method used

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  • Patterned hydrogel particle preparation method and microfluidic device
  • Patterned hydrogel particle preparation method and microfluidic device
  • Patterned hydrogel particle preparation method and microfluidic device

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Embodiment Construction

[0032] The technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Apparently, the described embodiments are some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0033] figure 1 It is a schematic diagram of the microfluidic device of the present invention, such as figure 1 As shown, the microfluidic device includes:

[0034] Microfluidic chip glue supply system 1, used to input the dispersed phase solution;

[0035] The capillary injection system 2 is used to input the dispersed phase solution output by the microfluidic chip glue supply system 1, and inject gas to cut the dispersed phase solution to form hydrogel particles with a multi-compartment structure.

[0036...

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Abstract

The invention provides a patterned hydrogel particle preparation method and a micro-fluidic device. The device comprises: a micro-fluidic chip glue supply system comprising a micro-fluidic chip, wherein the micro-fluidic chip inputs a dispersed phase solution to form a laminar flow structure; and a capillary injection system used for inputting the dispersed phase solution with the laminar flow structure and introducing gas to cut the dispersed phase solution so as to form the hydrogel particles with the multi-compartment structure. According to the invention, pneumatic drive is used as a power source to complete cutting preparation of dispersed phase liquid drops, and the method is green, safe, flexible and changeable and can be used for manufacturing hydrogel particles of various structures.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a method for preparing patterned hydrogel particles and a microfluidic device. Background technique [0002] In recent years, the configuration of multipurpose hydrogel materials into heterogeneous particles in biomedical applications has received considerable attention. These anisotropic hydrogel particles have been used to solve problems such as drug loading, cell culture, food additives, and controllable microreactions. In addition, more complex applications pose challenges to high-order hydrogel structures, and the precise spatial arrangement of gels is conducive to broadening the application range of hydrogel droplets, thus helping people to deal with more complex challenges. [0003] The preparation technology of patterned hydrogel particles is not yet perfect, and four methods are generally used: droplet technology based on coaxial capillary microfluidic syst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01J13/00
CPCB01L3/5027B01L3/502784B01J13/0052B01L2200/10B01L2300/0861B01L2300/0887B01L2400/0406B01L2400/0487
Inventor 林金明吴增楠
Owner TSINGHUA UNIV
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