Immunogenic oligopeptide aiming at ETAR-RhoE pathway, vaccine of immunogenic oligopeptide and application of immunogenic oligopeptide in improvement of heart remodeling

An immunogenic and pathway technology, applied in the field of biomedicine, to improve cardiac remodeling, alleviate cardiac remodeling, and improve cardiac function

Active Publication Date: 2021-07-09
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, there are currently no research reports and related invention patents on the construction of therapeutic short peptides targeting endothelin receptors against cardiac remodeling

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  • Immunogenic oligopeptide aiming at ETAR-RhoE pathway, vaccine of immunogenic oligopeptide and application of immunogenic oligopeptide in improvement of heart remodeling
  • Immunogenic oligopeptide aiming at ETAR-RhoE pathway, vaccine of immunogenic oligopeptide and application of immunogenic oligopeptide in improvement of heart remodeling
  • Immunogenic oligopeptide aiming at ETAR-RhoE pathway, vaccine of immunogenic oligopeptide and application of immunogenic oligopeptide in improvement of heart remodeling

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Embodiment Construction

[0044] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments.

[0045] The present invention to ET A Analysis of the molecular structure of R: ET A R and ET B R all belong to G protein-coupled receptors, and their amino acid sequences have high homology in mammals. As a typical 7-transmembrane receptor, ET A R and ET B All R structures include: extracellular N-terminal, intracellular C-terminal, 7 transmembrane domains, 3 extracellular loops (EC1, EC2 and EC3) and 3 intracellular loops. Of particular importance: the first transmembrane domain and the first extracellular loop (EC1) of the endothelin recept...

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Abstract

The invention discloses an immunogenic oligopeptide aiming at an ETAR-RhoE pathway, a vaccine of the immunogenic oligopeptide and an application of the immunogenic oligopeptide to improvement of heart remodeling, and belongs to the field of biological medicine, the oligopeptide is coupled with carrier hemocyanin KLH or tetanus toxoid through a glutaraldehyde coupling method to form hapten oligopeptide-carrier protein (complete antigen: RG10 therapeutic oligopeptide). The therapeutic oligopeptide can stimulate a body to generate a target antibody with high antibody titer and lasting titer by being supplemented with an adjuvant. The RG10 therapeutic oligopeptide can be developed as an efficient and brand-new therapeutic means for clinically improving heart remodeling, and has great future application potential.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a short peptide for improving cardiac remodeling and its pharmaceutical application, especially a short peptide for ET A Immunogenic short peptides of the R-RhoE pathway and their application for vaccines and improving cardiac remodeling. Background technique [0002] Cardiac remodeling includes myocardial hypertrophy and fibrosis, inflammatory cell infiltration in cardiac tissue, myocardial cell mitochondrial damage, myocardial autophagy dysfunction and cell apoptosis, which lead to the occurrence and development of heart failure, and eventually progress to end-stage heart failure and death (Sposato Luciano A.J Am Coll Cardiol, 2020, 76:2768-2785). In clinical work, conventional drug therapy for cardiac remodeling imposes a heavy economic burden on patients (Emdin Michele. J Am Coll Cardiol, 2020, 76:1795-1807). However, although anti-cardiac remodeling drugs such as ACEI, ARBs, Nuxint...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K39/00A61K39/385A61P9/00
CPCC07K7/06A61K39/0005A61K39/385A61P9/00A61K2039/6081A61K2039/6037A61K2039/55566
Inventor 程征董禹辰
Owner XI AN JIAOTONG UNIV
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