Composition with weight losing function and containing levocarnitine or acetyl-L-carnitine and yohimbine and application of composition

A composition, the technology of yohimbine, the application in the preparation, the yohimbine or its pharmaceutically acceptable salt, the preparation for reducing body weight and body fat, the pharmaceutical composition field of the excipient, can solve the fatty acid oxidation Process weakening and other problems to achieve the effect of increasing energy metabolism, preventing obesity, and inhibiting proliferation

Inactive Publication Date: 2021-07-16
北京华睿鼎信科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when L-carnitine is insufficient or the mitochondrial transport system on which L-carnitine depends is defective, the fatty acid oxidation process is greatly weakened

Method used

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  • Composition with weight losing function and containing levocarnitine or acetyl-L-carnitine and yohimbine and application of composition
  • Composition with weight losing function and containing levocarnitine or acetyl-L-carnitine and yohimbine and application of composition
  • Composition with weight losing function and containing levocarnitine or acetyl-L-carnitine and yohimbine and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of embodiment 1 levocarnitine and yohimbine composition dry suspension (1000 bags of prescriptions)

[0029]

[0030]

[0031] Take the raw and auxiliary materials, pulverize them, pass through a 200-mesh sieve respectively, dry them in an appropriate way, and set aside; weigh the raw and auxiliary materials according to the prescription amount, and use physical mixing method to directly mix them evenly. The process should be as fast as possible to minimize the entry of water; mix evenly The final powder is evenly put into aluminized film bag, and it is ready. Embodiment 2 Preparation of acetyl-levocarnitine fumarate and yohimbine granules (1000 bags of prescription)

Embodiment 2

[0031] Take the raw and auxiliary materials, pulverize them, pass through a 200-mesh sieve respectively, dry them in an appropriate way, and set aside; weigh the raw and auxiliary materials according to the prescription amount, and use physical mixing method to directly mix them evenly. The process should be as fast as possible to minimize the entry of water; mix evenly The final powder is evenly put into aluminized film bag, and it is ready. Embodiment 2 Preparation of acetyl-levocarnitine fumarate and yohimbine granules (1000 bags of prescription)

[0032]

[0033] Pass the bulk drug through an 80-mesh sieve and set aside. The sucrose and gum arabic are pulverized in a high-speed multifunctional pulverizer, and passed through a 60-mesh sieve for later use, and other auxiliary materials are respectively passed through a 60-mesh sieve for later use. Weigh the prescribed amount of hydroxypropyl cellulose, add an appropriate amount of purified water to dissolve it, stir even...

Embodiment 3

[0034] The preparation of embodiment 3 levocarnitine and yohimbine hydrochloride capsules (2000 prescriptions)

[0035]

[0036] The raw and auxiliary materials of the prescription amount are weighed, and the raw materials are passed through a 100-mesh sieve, and the auxiliary materials are respectively passed through an 80-mesh sieve. Thoroughly mix levocarnitine, yohimbine hydrochloride, pregelatinized starch, sodium lauryl sulfate and magnesium stearate evenly. Adjust the capsule filling machine to control the difference in filling volume at ±5%, and then fill it to obtain the product.

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PUM

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Abstract

The invention provides a pharmaceutical composition for losing weight and fat, and provides a preparation method of the pharmaceutical composition and an application of the pharmaceutical composition in the weight and fat losing process. The composition comprises (i) levocarnitine or a pharmaceutically acceptable salt of the levocarnitine, or acetyl-L-carnitine or a pharmaceutically acceptable salt of the acetyl-L-carnitine and (ii) yohimbine or a pharmaceutically acceptable salt of the yohimbine. The composition has the effects of losing weight and reducing body weight and body fat.

Description

technical field [0001] The present invention belongs to the field of preparations, and specifically relates to (i) levocarnitine or acetyl levocarnitine or a pharmaceutically acceptable salt thereof, (ii) yohimbine or a pharmaceutically acceptable salt thereof, and (iii) one or Pharmaceutical compositions with various pharmaceutically acceptable excipients. The present invention also provides an application of the composition, especially an application of the composition in preparing a preparation for reducing body weight and body fat. The present invention also provides an application of a preparation comprising the composition, especially a preparation that can be used for reducing body weight and reducing body fat. Background technique [0002] In today's society, with the continuous advancement of science and technology and the great abundance of material resources, people's quality of life has been greatly improved. However, the ensuing "rich man's disease" is also spr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/475A61K31/205A61P3/04A23L33/10A23L33/105
CPCA23V2002/00A61K31/205A61K31/475A23L33/10A23L33/105A61P3/04A61K2300/00A23V2200/332A23V2250/21A23V2250/1628A23V2250/264A23V2250/628A23V2250/5086A23V2250/51086A23V2250/5114A23V2250/5084A23V2250/5022A23V2250/5118A23V2250/1582A23V2250/1614A23V2250/26A23V2250/28
Inventor 安明况斌高峥
Owner 北京华睿鼎信科技有限公司
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