Method and system for generating animal heart failure and atrial fibrillation combined model

Abstract

The invention belongs to the field of medical animal experiments and particularly relates to a method and a system for generating an animal heart failure and atrial fibrillation combined model. The method comprises the following steps: a wireless communication connection between a model generation system and a three-cavity pacemaker in an experimental large animal body is established, wherein the three-cavity pacemaker is recycled from a patient with clinical pacemaker implantation; the model generation system receives monitoring signals of atrial electrical activity and ventricular electrical activity sent by the three-cavity pacemaker; and the model generation system extracts data of atrial fibrillation duration time, data of atrial fibrillation load rate and data of intrathoracic impedance from the monitoring signals by adopting a preset signal corresponding relation, and generates an animal heart failure and atrial fibrillation combined model. The method can simply, conveniently and economically construct a stable and reliable heart failure and atrial fibrillation combined model of large animals, and is suitable for animal modeling experiments in medical research.

Description

technical field [0001] The invention belongs to the field of medical animal experiments, and in particular relates to a method and a system for generating an animal heart failure combined with atrial fibrillation model. Background technique [0002] Chronic heart failure (heart failure) and atrial fibrillation (AF) are one of the most common arrhythmia diseases. Because they have similar risk factors and pathophysiological processes, they often cause and affect each other. Studies have shown that more than 50% of patients with heart failure will develop atrial fibrillation later, and more than 30% of patients with atrial fibrillation will develop heart failure. In fact, it is very common for the two types of diseases to coexist clinically, and the prognosis is significantly worse than that of a single disease. The structural and functional characteristics of the hearts of large animals such as dogs, pigs, and sheep are very similar to the human heart. The construction of ex...

AI Technical Summary

Problems solved by technology

This method has limitations: the special pacemakers sold on the market are very expensive, with a single price ranging from 20,000 to 50,000 yuan; although it has been reported that the use of clinical recycling of discarded dual-chamber pacemakers can solve the problem of cost, but the pacemaker under this method The state of fibrillation usually needs to be induced by electrophysiological examination, and the duration is usually short. If atrial fibrillation terminates spontaneously, electrophysiological examination needs to be induced again.

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