Microvascular Tree Generation Method Based on Conditional Generative Adversarial Network and Constraint Rules

Abstract

The present invention provides a microvascular tree generation method based on conditional generative confrontation network and constraint rules. The method is based on conditional generative confrontation network, and the new model of microvascular tree established by conditional generative confrontation network utilizes the condition of upper-level bifurcation weakening to generate Generate the next level fork. This model only needs to give the entrance bifurcation, and the microvascular tree can be generated by step-by-step growth. At the same time, the optimization conditions of vascular density and bifurcation angle are added during the growth process, and the growth angle can be carefully corrected, and a microvascular tree with a more uniform vascular density can be obtained during the growth process, which is more in line with the microvascular network in transporting oxygen. And the physiological requirements of the process of metabolizing nutrients, so that the generated microvascular tree not only conforms to the morphological characteristics but also indirectly conforms to part of the physiological characteristics.

Description

technical field [0001] The invention relates to a method for generating a microvascular tree based on a conditional generation confrontation network and constraint rules, and belongs to the field of biomedicine. Background technique [0002] Angiogenesis is an important link in the development of vascular network. It is a process in which blood vessels grow and develop into a vascular tree and vascular network under the action of blood flow, metabolism, material exchange and other physiological needs, and also provide oxygen and nutrients for the further development and growth of organisms. An important process of excretion of metabolites. It is of great significance to study the mechanism of angiogenesis in many research fields. However, vascular network regeneration is a physiological process involving multiple time scales. It is difficult to observe short and long-term physiological processes simultaneously by controlling experimental conditions in animal experiments, a...

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Problems solved by technology

However, vascular network neogenesis is a physiological process involving multiple time scales. It is difficult to observe short and long-term physiological processes at the same time by controlling experimental conditions in animal experiments, and the process of obtaining a real microvascular network is difficult and complicated.

Traditional methods are mostly based on statistics and fractal theory to generate microvascular trees. The generated microvascular trees have high homogeneity and cannot reflect the real microvascular tree structure with high heterogeneity.

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