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Pharmaceutical composition of forskolin/isoforskolin and pentacyclic triterpenoids and application thereof

A technology of pentacyclic triterpenoids and compositions, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effect of reducing fat accumulation, inhibiting liver fibrosis, and wide application value

Active Publication Date: 2021-08-13
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] At present, there is no report on forskolin / iforeskolin combined with pentacyclic triterpenoids for the prevention and treatment of metabolic diseases, fibrosis diseases and liver diseases

Method used

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  • Pharmaceutical composition of forskolin/isoforskolin and pentacyclic triterpenoids and application thereof
  • Pharmaceutical composition of forskolin/isoforskolin and pentacyclic triterpenoids and application thereof
  • Pharmaceutical composition of forskolin/isoforskolin and pentacyclic triterpenoids and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: The therapeutic effect of the pharmaceutical composition of the present invention on the obesity model and fatty liver model induced by high-fat diet.

[0045] Comparing the therapeutic effect of forskolin / isoforskolin and pentacyclic triterpenoids combined administration and single administration on obesity and fatty liver model induced by high-fat feed, to verify the synergistic treatment of the composition of the present invention Effect.

[0046] 1. Establishment of non-alcoholic fatty liver model mice

[0047] After adaptive feeding of 160 male C57 mice of SPF grade 8-9 weeks old for one week, 140 mice with uniform weight and obesity were selected and divided into 14 groups on average, with 10 mice in each group, which were model group (group M) , forskolin group (F group), isofuskolin group (IF group), asiatic acid group (AA group), asiatic acid group (AS group), oleanolic acid group (OA group) , betulinic acid group (BA group), forskolin + asiatic ac...

Embodiment 2

[0072] Embodiment 2 pharmaceutical composition of the present invention is to CCl 4 Therapeutic Effects of Induced Chronic Liver Fibrosis Model Comparing Forskolin Combined with Pentacyclic Triterpenoids, and CCl Alone 4 The therapeutic effect of the induced chronic liver fibrosis model mice to verify the synergistic therapeutic effect of the composition of the present invention.

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PUM

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Abstract

The present invention relates to a pharmaceutical composition comprising two components, the first component being selected from forskolin, isoforskolin or a pharmaceutically acceptable salt thereof; and the second component is selected from pentacyclic triterpenoids or pharmaceutically acceptable salts thereof. According to the pharmaceutical composition disclosed by the invention, forskolin / isoforskolin and the pentacyclic triterpenoids are combined for use, and compared with independent use of the two components, the pharmaceutical composition disclosed by the invention can achieve a remarkable synergistic effect on prevention and treatment of metabolic, fibrosis and liver diseases, so that the pharmaceutical composition has a wide medicinal prospect in the aspect of improving diseases such as obesity, non-alcoholic fatty liver disease, liver injury, hepatic fibrosis and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition comprising forskolin / iforeskolin and pentacyclic triterpenoids and its preparation for preventing, improving or treating metabolic diseases, fibrosis diseases and liver diseases use in . Background technique [0002] With the improvement of the economic level, people's dietary structure has changed greatly, the intake of lipids has increased, and the obese population has gradually expanded. The World Health Organization (WHO) defines people with a body mass index (BMI) ≥ 25 as overweight. Obesity can be Causes the occurrence of various metabolic diseases, such as diabetes, hypertension, hyperlipidemia, fatty liver and so on. Non-alcoholic fatty liver disease (NAFLD) is a type of disease characterized by lipid accumulation and degeneration in liver cells. Its pathological section mainly shows that lipid droplets in liver cells increase significantly, and inflamm...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/56A61K31/7024A61K31/352A61P3/10A61P3/06A61P3/04A61P9/00A61P9/10A61P13/12A61P11/00A61P17/00A61P1/16A61P35/00
CPCA61K45/06A61K31/352A61K31/56A61K31/7024A61P3/10A61P3/06A61P3/04A61P9/00A61P9/10A61P13/12A61P11/00A61P17/00A61P1/16A61P35/00A61K2300/00A61K31/704
Inventor 吴亮
Owner CHINA PHARM UNIV
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