Cyclic peptide capable of reducing insulin and properly reducing blood sugar at same time

A technology for insulin and blood sugar, applied in the direction of cyclic peptide components, enzymes, biochemical equipment and methods, etc., can solve the problems of no rise in blood sugar, no decrease in insulin, etc., and achieve the effects of lowering blood sugar, improving stability, and reducing amplitude

Pending Publication Date: 2021-08-20
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no drug that lowers insulin without raising blood sugar, and there is no drug that lowers insulin while lowering blood sugar.

Method used

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  • Cyclic peptide capable of reducing insulin and properly reducing blood sugar at same time
  • Cyclic peptide capable of reducing insulin and properly reducing blood sugar at same time
  • Cyclic peptide capable of reducing insulin and properly reducing blood sugar at same time

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In order to detect the stability of the peptide in the gastrointestinal tract, after incubation with simulated gastrointestinal fluid in vitro, it was found by HPLC-MS that the short peptide COX 52-69 Can exist stably in simulated gastrointestinal fluid.

Embodiment 2

[0024] The experimental group used the modified peptide COX 52-69 The SD rats were intragastrically administered, and the control group used the same dose of 0.9% normal saline to intragastrically administer the SD rats. Both groups were intragastrically administered 20% glucose solution, and at the end of 0, 30, 60, 90, and 120min Take blood from the vein, and use ELISA (enzyme-linked immunosorbent technique) to detect the insulin content in the blood supernatant, such as image 3 , the insulin concentration of the experimental group was significantly lower than that of the control group, and there was a statistically significant difference; Figure 4 , the increase in blood sugar in the experimental group was significantly lower than that in the control group, indicating that the cyclic peptide did not cause an increase in blood sugar while reducing insulin, but had a role in lowering blood sugar. Insulin is lowered without raising blood sugar, which can be used in many sit...

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Abstract

The invention relates to a cyclic peptide capable of reducing insulin, not increasing blood sugar but properly reducing blood sugar at the same time, and belongs to the technical field of biological pharmacy. The bifunctional cyclic peptide is obtained through in-vitro modification on the basis of an original linear short peptide COX52-69; the effects of two seemingly contradictory aspects are achieved; namely, the effect of inhibiting insulin secretion but not increasing blood sugar at the same time is achieved; blood sugar is reduced; and the mechanism of the bifunctional cyclic peptide is possibly to improve the sensitivity of tissue to insulin. It is called as a bifunctional peptide. The bifunctional peptide can be used for congenital insulinemia, insulin tolerance, hyperinsulinemia of obese people and the like; literatures report that insulin increase is the reason of obesity; but people cannot lose weight through a method of reducing insulin all the time; and because blood sugar is increased after insulin is reduced, hyperglycemia is more adverse to health. The cyclic peptide realizes the function that the blood sugar is not increased but is reduced while insulin is reduced, so that a new medicine is developed for treating obesity; and the medicine not only can be administrated by injection, but also can be conveniently administrated by oral administration. The convenience of using the medicine is greatly improved.

Description

[0001] The invention relates to a cyclic peptide that not only lowers insulin but also properly lowers blood sugar, and belongs to the technical field of biopharmaceuticals. The bifunctional cyclic peptide is the original linear short peptide COX 52-69 Based on in vitro modification and modification, two seemingly contradictory effects are achieved, that is, the effect of inhibiting insulin secretion without raising blood sugar, and even lowering blood sugar. The mechanism may be to increase the tissue's response to insulin. sensitivity. We call these bifunctional peptides. technical field [0002] The invention relates to a drug that inhibits insulin secretion without increasing blood sugar, on the contrary, has a certain effect of lowering blood sugar. This is a phenomenon that has not been found so far. The invention belongs to the field of biochemical pharmacy polypeptide medicine. Background technique [0003] As we all know, insulin is currently the only hormone th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61P3/10A61P5/50A61P3/04C12N9/02
CPCA61K38/12A61P3/04A61P3/10A61P5/50C12N9/0053C12Y109/03001
Inventor 李臣鸿李知宗
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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