Markers and their applications for the diagnosis, stratification and prognosis of thyroid cancer

A thyroid cancer and marker technology, applied in the field of medical detection, can solve the problems of high false negative, low sensitivity and inaccuracy, and achieve the effect of high accuracy, high sensitivity and convenient detection

Active Publication Date: 2022-05-03
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical diagnosis of cervical lymph node metastases is not accurate: preoperative ultrasound has high specificity for judging cervical lymph node metastases, but its sensitivity is low; intraoperative frozen pathology can also give clinical hints, but its false The negative rate is high, and the incidence of lymph node metastases confirmed by paraffin pathology is as high as 30% for patients who are evaluated as negative for cervical lymph node metastases before operation. Waiting for intraoperative pathology also inevitably prolongs the operation time
Due to the presence of occult metastasis in many patients and the limitations of the above-mentioned technical means, it is difficult to accurately determine whether a patient has lymph node metastasis before surgery
Whether routine preventive neck dissection is also controversial for PTC

Method used

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  • Markers and their applications for the diagnosis, stratification and prognosis of thyroid cancer
  • Markers and their applications for the diagnosis, stratification and prognosis of thyroid cancer
  • Markers and their applications for the diagnosis, stratification and prognosis of thyroid cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Example 1 Markers are used to distinguish between healthy controls and thyroid nodules (benign nodules+malignant nodules)

[0078] 96 sugar chain structures were detected in the thyroid cancer research cohort (including thyroid cancer, benign thyroid nodules, and healthy controls, Table 3), and 91 sugar chain structures were calculated based on the structural characteristics and biological synthesis pathways of these directly detected sugar chains. The characteristics of a derived sugar chain. Since the derived feature summary represents the structural features of the directly detected glycans and helps to interpret the results and biological effects, the derived glycan features were mainly analyzed.

[0079] Of the 91 derived sugar chain signatures found above, 23 derived sugar chain signatures had significant differences between healthy controls and thyroid nodules (Table 4). The results showed that, compared with healthy controls, tetraantennary complex (CA4), fucos...

Embodiment 2

[0085] Example 2 Markers are used to distinguish malignant thyroid nodules (thyroid cancer) from benign thyroid nodules

[0086] 96 sugar chain structures were detected in the thyroid cancer research cohort (including thyroid cancer, benign thyroid nodules, and healthy controls, Table 3), and 91 sugar chain structures were calculated based on the structural characteristics and biological synthesis pathways of these directly detected sugar chains. The characteristics of a derived sugar chain. Since the derived feature summary represents the structural features of the directly detected glycans and helps to interpret the results and biological effects, the derived glycan features were mainly analyzed.

[0087] Among the 91 kinds of derived sugar chain characteristics found above, there are 4 kinds of derived sugar chain characteristics, that is, the median values ​​of CFa, A2Fa, A2L, and A2GL showed continuous changes in malignant thyroid nodules, benign nodules and healthy contr...

Embodiment 3

[0090] Example 3 Markers are used to distinguish thyroid cancer from non-cancerous controls (benign nodules+healthy controls)

[0091]The analysis method is the same as that in Example 2. The median values ​​of the four derived sugar chain features, CFa, A2Fa, A2L, and A2GL, are significantly different between thyroid cancer and non-cancer controls (benign nodules + healthy controls) (t test, p Figure 5 , Table 6), proving that the body fluid glycogen index CFa, A2Fa, A2L, A2GL can distinguish thyroid cancer and non-cancer controls with high accuracy. When the four sugar chain features are used in combination, the discrimination accuracy is improved (Table 6).

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Abstract

The invention relates to the technical field of medical detection, in particular to markers for diagnosis, stratification and prognosis of thyroid cancer and applications thereof. The present invention provides markers for thyroid nodules, which include a combination of one or more of the following N-sugar chain markers: CFa, A2Fa, A4G, A4S, A4FOS, A4L, A4E, A4FOE. The present invention also provides a marker for thyroid cancer, which includes a combination of one or more of the following N-sugar chain markers: CFa, A2Fa, A2L, A2GL. The expression levels of the N-sugar chain markers provided by the present invention are significantly different among healthy people, thyroid nodules, thyroid cancer and patients with cervical lymph node metastasis of thyroid cancer, and can be used for the diagnosis of thyroid nodules and the discrimination of benign and evil thyroid tumors , The discrimination of cervical lymph node metastasis of thyroid cancer has high specificity, sensitivity and accuracy.

Description

technical field [0001] The invention relates to the technical field of medical detection, in particular to markers for diagnosis, stratification and prognosis of thyroid cancer and applications thereof. Background technique [0002] Thyroid cancer (TC) is the most common malignancy of the endocrine system. In recent years, its incidence has increased significantly. Thyroid cancer is mainly divided into four pathological types, and more than 90% of thyroid malignancies are papillary thyroid carcinoma (PTC). Epidemiological studies have shown that the palpation rate of thyroid nodules is about 5% in women and 1% in men. About 5-15% of the nodules will develop malignant lesions, which require timely surgery or other treatment, and the rest of the benign nodules need standardized follow-up. In addition, although the overall prognosis of differentiated thyroid cancer dominated by PTC is good, the proportion of lesions that obviously invade the surrounding important structures ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/72G01N29/02
CPCG01N30/02G01N30/06G01N30/7233G01N33/57488G01N30/08A61B8/08G01N2030/067G01N2030/085
Inventor 徐协群张泽建
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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