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Calcium supplement composition containing vitamin K2 as well as preparation method and application thereof

A composition and vitamin technology, applied to medical preparations containing active ingredients, medical preparations without active ingredients, drug combinations, etc., can solve problems such as constipation and inability to supplement calcium, achieve uniform release and improve stability sexual effect

Active Publication Date: 2021-08-31
SHANDONG RUNDE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this kind of calcium supplement products not only cannot play the role of calcium supplement for people with insufficient secretion of gastric juice, but will cause the problem of constipation

Method used

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  • Calcium supplement composition containing vitamin K2 as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A calcium supplement composition containing vitamin K2 and its preparation method and application, comprising the following steps:

[0029] (1) Grinding 25 parts by weight of calcium carbonate, 1.1 parts by weight of vitamin K2 and 0.5 parts by weight of vitamin D3 and mixing them uniformly, then adding 14 parts by weight of glycerin and 0.8 parts by weight of phospholipid and stirring evenly to obtain a calcium composition slurry.

[0030] (2) Take a part of the calcium composition slurry and place it in a granulator for granulation, and then dry it to obtain calcium composition granules with an average diameter of about 3mm, which are set aside.

[0031] (3) The 0.7 parts by weight of gelatin, 0.5 parts by weight of glycerin and 0.8 parts by weight of water are mixed and halved evenly to obtain the slurry of the slow-release layer, which is set aside.

[0032] (4) Immerse the calcium composition granules prepared in step (2) into the slurry of the slow-release layer p...

Embodiment 2

[0035] A calcium supplement composition containing vitamin K2 and its preparation method and application, comprising the following steps:

[0036] (1) Grinding 20 parts by weight of calcium carbonate, 0.5 parts by weight of vitamin K2 and 0.2 parts by weight of vitamin D3 and mixing them uniformly, then adding 12 parts by weight of glycerin and 0.4 parts by weight of phospholipid and stirring evenly to obtain a calcium composition slurry.

[0037] (2) Take a part of the calcium composition slurry and place it in a granulator for granulation, and then dry it to obtain calcium composition granules with an average diameter of about 2mm, which are ready for use.

[0038] (3) The 0.5 parts by weight of gelatin, 0.4 parts by weight of glycerin and 0.6 parts by weight of water are mixed and halved evenly to obtain a slurry of the slow-release layer, which is set aside.

[0039] (4) Immerse the calcium composition granules prepared in step (2) into the slurry of the slow-release layer...

Embodiment 3

[0042] A calcium supplement composition containing vitamin K2 and its preparation method and application, comprising the following steps:

[0043] (1) 35 parts by weight of calcium carbonate, 1.8 parts by weight of vitamin K2, and 1.5 parts by weight of vitamin D3 were pulverized and mixed uniformly, and then 17 parts by weight of glycerin and 1.2 parts of phospholipid were added and stirred evenly to obtain a calcium composition slurry.

[0044] (2) Take a part of the calcium composition slurry and place it in a granulator for granulation, and then dry it to obtain calcium composition granules with an average diameter of about 3mm, which are set aside.

[0045] (3) The 0.8 parts by weight of gelatin, 0.7 parts by weight of glycerin and 1.0 parts by weight of water are mixed and halved evenly to obtain the slurry of the slow-release layer, which is set aside.

[0046] (4) Immerse the calcium composition granules prepared in step (2) into the slurry of the slow-release layer pr...

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Abstract

The invention relates to the technical field of vitamin K2 preparation, in particular to a calcium supplement composition containing vitamin K2 as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) inoculating flavobacterium into a culture medium for fermentation, adding a settling accelerator into fermentation liquor after fermentation is completed, and separating thalli for later use after the thalli in the fermentation liquor are settled; (2) freeze-drying the thalli, crushing the thalli into powder, mixing the powder with acetone, extracting, and taking an extract liquor for later use after the extraction is completed; (3) adding clear water into the extract liquor, and separating out the precipitate after the precipitate is completely separated out, so as to obtain a crude product of the vitamin K2 product; and (4) mixing the crude product of the vitamin K2 product with acetone again for extraction, then adding clear water, and separating out a precipitate after the precipitate is completely separated out, thereby obtaining the vitamin K2 product. The method provided by the invention not only can effectively extract the vitamin K2 in the flavobacterium, but also has the characteristics of convenience in extraction and suitability for industrial application.

Description

technical field [0001] The invention relates to the field of vitamin K2 compositions, in particular to a calcium supplement composition containing vitamin K2 and its preparation method and application. Background technique [0002] Vitamins are very important to the body. People’s bones, heart health, brain and nervous system health are inseparable from vitamins. Natural vitamin K includes vitamin K1 and vitamin K2. Among them, the fermentation process of vitamin K2 is mainly liquid Fermentation process, which generally uses glucose, dextrin, and glycerin as the main carbon source, soybean peptone and yeast powder as the main nitrogen source, and Bacillus natto, Bacillus subtilis, Flavobacterium, etc. Fermentation is carried out in the medium, and finally vitamin K2 products are made after extraction, purification and other processes. [0003] Because vitamin K2 has a unique side chain structure, it can help the primary osteocalcin secreted by osteoblasts to "carboxylate" a...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K33/10A61K45/06A61K47/42A61K47/10A61P3/02A61P9/10A61P9/12A61P19/02A61P25/16A61K31/122A61K31/593
CPCA61K9/5073A61K9/5057A61K9/5089A61K33/10A61K31/122A61K31/593A61K45/06A61P3/02A61P9/10A61P19/02A61P9/12A61P25/16A61K2300/00
Inventor 卢健行马善丽李飞张建华尹训娟卢建功
Owner SHANDONG RUNDE BIOTECH CO LTD
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