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Cyclobenzaprine sustained-release granule

A technology of cyclobenzaprine and sustained-release granules, which is applied in the field of medicine, can solve the problems of slow elimination, poor patient compliance, influence on curative effect, etc., and achieve the effects of reducing dosage, convenient taking and stable product quality.

Inactive Publication Date: 2020-08-18
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, cyclobenzaprine is eliminated slowly in the body (the elimination half-life is 32 hours), so the long-release preparations are administered multiple times in small doses during the day to avoid adverse reactions, resulting in poor patient compliance and affecting the curative effect

Method used

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  • Cyclobenzaprine sustained-release granule
  • Cyclobenzaprine sustained-release granule
  • Cyclobenzaprine sustained-release granule

Examples

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preparation example Construction

[0026] A preparation method for cyclobenzaprine sustained-release granules, comprising the following steps:

[0027] (1) Mix cyclobenzaprine and filler evenly, and use 85% ethanol as a binding agent to make a 20-24 purpose quick-release granule core for subsequent use;

[0028] (2) Dissolving the slow-release material, plasticizer, porogen, and anti-tack agent with 80% ethanol to make a slow-release coating solution;

[0029] (3) Evenly spray the prepared sustained-release coating solution on the surface of the immediate-release granule core prepared in step (1), and obtain cyclobenzaprine sustained-release granules after drying.

Embodiment 1

[0030] Example 1 Preparation of Cyclobenzaprine Sustained Release Granules

[0031] Cyclobenzaprine sustained-release granules are prepared according to the raw and auxiliary materials in the following prescription and the above-mentioned preparation method.

[0032] Cyclobenzaprine 25g

[0033] Microcrystalline Cellulose 325g

[0034] Carboxymethyl ethyl cellulose 200g

[0035] Dibutyl phthalate 100g

[0036] Povidone 50g

[0037] Magnesium Stearate 50g

Embodiment 2

[0038] Example 2 Preparation of cyclobenzaprine sustained-release granules

[0039] Cyclobenzaprine sustained-release granules are prepared according to the raw and auxiliary materials in the following prescription and the above-mentioned preparation method.

[0040] Cyclobenzaprine 25g

[0041] Microcrystalline Cellulose 325g

[0042] Carboxymethyl ethyl cellulose 200g

[0043] Dibutyl phthalate 100g

[0044] Sucrose 50g

[0045] Magnesium Stearate 50g

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Abstract

The invention discloses a cyclobenzaprine sustained-release granule and a preparation method thereof. The cyclobenzaprine sustained-release granule is composed of a quick-release granule core and a sustained-release coating layer, the quick-release granule core is composed of cyclobenzaprine and a filler, the sustained-release coating layer is composed of a sustained-release material, a plasticizer, a pore-foaming agent and an anti-sticking agent, and the cyclobenzaprine sustained-release granule is prepared by wrapping the quick-release granule core with the sustained-release coating layer. The medicine disclosed by the invention is convenient to take and uniform and slow to release, and can achieve the purposes of long-acting and curative effect increasing; and meanwhile, the dosage is reduced while the same drug effect is maintained, so that the side effect of the drug on a patient is reduced.

Description

technical field [0001] The invention relates to a western medicine preparation technology, in particular to a cyclobenzaprine sustained-release granule, which belongs to the technical field of medicine. Background technique [0002] Musculoskeletal system diseases are more common in clinical practice, involving bones, intervertebral discs, nerves, muscles, joints, soft tissues and other diseases. There are also many causes of musculoskeletal pain, such as inflammation, mechanical injury, immune reasons, tumors, etc. The International Society for Pain (IASP) pointed out that musculoskeletal pain is the pain with the highest incidence and the largest range of impact among all pains, and even about half of the population suffers from musculoskeletal pain for more than 3 months in a year. Musculoskeletal pain occurs frequently and is classified into neck pain, back and lower back pain, joint pain, etc. depending on the site of attack. Often cause long-term, chronic injury to th...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K47/38A61K47/14A61K47/26A61K31/135A61P21/02A61P29/00
CPCA61K9/5015A61K9/5047A61K31/135A61P21/02A61P29/00
Inventor 臧云龙陈阳生刘晓霞孙桂玉王明刚刘振玉张怀征耿立朵李洁
Owner CP PHARMA QINGDAO CO LTD
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