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Application of gene group as detection index in oral squamous cell carcinoma diagnosis

A technology in oral squamous cell carcinoma and samples, which is applied in the field of biomedicine and can solve problems such as poor prognosis

Pending Publication Date: 2021-08-31
BEIJING MEDINTELL BIOMED CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although surgery combined with drug therapy has achieved some clinical results in patients with oral cancer, the prognosis of patients is still not optimistic (Kim B B, Kim D D. The role of dental care providers and oral and maxillofacial surgeons in the surgical and medical management of oral cancer in the United States[J]. General Dentistry,2013,61(7):47.), especially those with distant metastasis

Method used

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  • Application of gene group as detection index in oral squamous cell carcinoma diagnosis
  • Application of gene group as detection index in oral squamous cell carcinoma diagnosis
  • Application of gene group as detection index in oral squamous cell carcinoma diagnosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0080] Example Gene markers associated with the diagnosis of oral squamous cell carcinoma

[0081] 1. Data and preprocessing

[0082] Search public gene expression data and complete clinical annotations in the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). According to clinical information, select oral clinical specimens (alveolar ridge, buccal mucosa, floor of the mouth, tongue, lips, oral cavity, hard palate), exclude specimens from anatomical parts such as hypopharynx, larynx, oropharynx, tonsil, and remove those with incomplete clinical information sample.

[0083] For the datasets in TCGA, RNA-sequencing data of gene expression (FPKM values) and clinical information were downloaded from UCSC Xena (https: / / gdc.xenahubs.net). The tidyverse package was used to annotate the genes, the genes were deduplicated and averaged, and the FPKM was converted to the power of 2, and the FPKM value was converted into transcripts per kilobase million (TPM) value.

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Abstract

The invention discloses application of a gene group as a detection index in oral squamous cell carcinoma diagnosis. The gene group comprises CKMT2, GABRP and / or KRT23, expression of CKMT2, GABRP and KRT23 in oral squamous cell carcinoma patients is reduced, and whether a subject suffers from the oral squamous cell carcinoma or whether the risk of suffering from the oral squamous cell carcinoma exists or not can be judged by detecting the expression level of CKMT2, GABRP and / or KRT23. The invention also discloses an application of the CKMT2, the GABRP and / or the KRT23 in construction of a calculation model for predicting the oral squamous cell carcinoma.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of a gene group as a detection index in the diagnosis of oral squamous cell carcinoma. Background technique [0002] As one of the most common malignant tumors of the head and neck, oral cancer has the characteristics of fast growth, strong invasion, and prone to lymph node metastasis. Due to the rich blood vessels and lymphatic vessels in the human head and face, oral cancer is very prone to metastasis, and the common metastatic sites include gums, tongue, soft and hard palate, jawbone, floor of the mouth, oropharynx, salivary glands, upper and lower lips, upper frontal sinus, and face. Skin and mucous membranes (Ribeiro I P, Barroso L, Marques F, et al. Early detection and personalized treatment in oral cancer: the impact of omics approaches[J]. Molecular Cytogenetics, 2016, 9(1):85). The latest research shows that there are about 300,000 new cases of oral cancer in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574G01N33/68G01N33/573
CPCC12Q1/6886G01N33/57407G01N33/57484G01N33/68G01N33/573C12Q2600/158G01N2333/4742G01N2333/705G01N2333/9123
Inventor 燕飞刘欧胜易桥聂倩张帆涂画杨承刚
Owner BEIJING MEDINTELL BIOMED CO LTD