Particle formation and morphology
A particle, circularity technology, applied in chemical instruments and methods, medical preparations with non-active ingredients, peptides, etc., and can solve problems such as the limitation of circular particles
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Embodiment 1
[0585] A solution of sodium chloride (30 mg / mL) and surfactant (0.1% w / w) was prepared and processed using a rotating membrane emulsification system. The system consisted of a porous glass membrane with a median pore size of 5 microns, an outer diameter of 10 mm, an inner diameter of 9 mm, and an overall length of 4 mm, connected to a liquid pump via a tubular shaft and rotating coupling fitting. A rotational motion was applied to the membrane using an overhead mixer. The membrane was immersed in 300 mL of the second liquid and stirred using a magnetic stir bar in a glass container. The membrane was rotated at approximately 900 rpm while 3.0 mL of feed solution was pumped through the membrane at 1.5 mL / min. The dehydrated particles were separated from the second liquid using a 0.5 micron membrane filter and vacuum dried to remove residual solvent. SEM images show identifiable particulate matter.
Embodiment 2
[0587] Human IgG powder was reconstituted in deionized water to a protein concentration of approximately 60 mg / mL. The solution was desalted, and amounts of amino acids (12 mg / mL), carbohydrates (3 mg / mL), salts (2.1 mg / mL) and surfactants (1.8 mg / mL) were added. A solution droplet was formed in a stream of ethyl acetate using a flow focusing device. The flow focusing device consists of a sleeve-type assembly, ie a coaxial assembly, in which the inner tube is placed along the axis of the outer tube. The inner tube has an inner and outer diameter of approximately 100 microns and 360 microns, respectively. The outer tube has an inner and outer diameter of approximately 1 / 32" and 1 / 16", respectively. The cannula assembly was connected to the focusing capillary in such a way that the outlet of the inner tube and the inlet of the focusing capillary were separated by an axial distance of approximately 1 mm. The focusing tube had an inner and outer diameter of about 100 microns an...
Embodiment 3
[0589] Human IgG powder was reconstituted in deionized water to a protein concentration of approximately 50 mg / mL and desalted. Prepare an ethyl acetate solution containing the appropriate concentration of the appropriate surfactant to deagglomerate. A sample of the human IgG solution was nebulized and collected in a stainless steel vessel containing a volume of 5 V 0 solution in ethyl acetate, kept near room temperature with gentle stirring. A second sample of the human IgG solution was nebulized and collected in a stainless steel container containing a volume V 0 solution in ethyl acetate, kept near room temperature with gentle stirring. A third sample of human IgG solution was nebulized and collected in a stainless steel container containing a volume of 0.5 V 0 solution in ethyl acetate, kept near room temperature with gentle stirring. A fourth sample of human IgG solution was nebulized and collected in a stainless steel container containing a volume of 0.1 V 0 solutio...
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