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ANK tripeptide and application thereof

A drug and technology for inflammatory bowel disease, applied to ANK tripeptide and its application fields, can solve the problems of loss of immune tolerance and drug resistance, increased adverse reactions, and low efficacy, and achieve the effect of reducing the level of mRNA expression

Active Publication Date: 2021-09-17
JIANGXI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, current IBD drugs are associated with severe side effects, including loss of immune tolerance and drug resistance, infectious complications, endocrine damage, renal and hepatic damage (Nielsen, Bjerrum, Herfarth, & Rogler, 2013; Poitras, Gougeon, Binn, &Bouin,2008)
Current treatment regimens have low efficacy and increased adverse reactions are the main concerns of clinical treatment

Method used

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  • ANK tripeptide and application thereof
  • ANK tripeptide and application thereof
  • ANK tripeptide and application thereof

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Embodiment Construction

[0016] The concept of the present invention and the resulting technical effects will be clearly and completely described below with reference to the embodiments and the accompanying drawings, so as to fully understand the purpose, solutions and effects of the present invention.

[0017] 1. Verification of the anti-inflammatory activity of tripeptide ANK in an in vitro inflammatory model and its mechanism of action

[0018] 1. Establishment of an inflammation model

[0019] Take 3×10 5 Cells were seeded on a cell culture plate at a density of cells / mL, the medium was changed every 24 hours, and the cells were cultured for 5-7 days until the cells were confluent to about 85%. The culture medium was discarded and washed twice with HBSS buffer. First, different concentrations of tripeptide samples prepared with DMEM-F12 fresh medium containing 5% FBS were added for pre-incubation for 2 h, and then TNF-α was added to the culture plate (to make the final concentration 5 ng / mL) to c...

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PUM

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Abstract

The invention discloses ANK tripeptide. The amino acid sequence of the ANK tripeptide is Ala-Asn-Lys. Experiments prove that the ANK tripeptide can effectively reduce the expression level of proinflammatory factor mRNA, has certain medical value and can be used for developing food or medicines for preventing and / or assisting in treating inflammatory bowel diseases.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to the field of biologically active peptides, in particular to ANK tripeptides and applications thereof. Background technique [0002] Crohn's disease (CD) and ulcerative colitis (UC) are the two most important types of inflammatory bowel disease (IBD) and are one of the most serious diseases in the world except cardiovascular disease. The incidence and prevalence curve There is an upward trend over time. So far, the pathogenesis of IBD is not fully understood, and there are many influencing factors, such as: environmental factors, immune response factors, genetic factors, microbial factors, etc. (Arora et al., 2015). Although many advances have been made in the treatment of IBD, it remains an incurable disease. Clinically, the main treatment for UC is aminosalicylates. Severe UC patients can be treated with short-term steroids. If the above treatment methods still fail to relieve the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/083A61K38/06A61P1/00A61P29/00A23L33/18
CPCC07K5/0806A61P1/00A61P29/00A23L33/18A61K38/00A23V2002/00A23V2200/32A23V2250/55
Inventor 涂勇刚李媛赵燕徐明生姚瑶吴娜
Owner JIANGXI AGRICULTURAL UNIVERSITY
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