Combined medicine for treating ulcerative colitis and preparation method thereof
A technology for ulcerative colitis and drugs, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of high recurrence rate limiting the clinical use value of drugs, and the remission rate of less than 50%. Reduced mRNA expression level, low price, better effect
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[0020] (1) Modeling and administration methods
[0021] According to the random number table method, the C57BL / 6 mice were divided into blank control group, model group and drug intervention group, with 10 mice in each group. A mouse model of UC was induced using DSS. The mice were given 3% DSS solution to drink freely for 7 consecutive days, and replaced with regular drinking water on the 8th day of the experiment; the mice in the blank control group were given the same amount of regular drinking water from the first day to the tenth day. During the experiment, the body weight of the mice was monitored and recorded every day, and the consistency of the feces and blood in the stool of the mice were measured and recorded by the benzidine method to determine whether the model was successful.
[0022] The drug intervention group was given different concentrations of drugs for intragastric administration from the first day to the tenth day, and the blank control group and the mod...
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