A titanium-based implant for promoting osseointegration and its preparation method and application
An implant, titanium-based technology, used in prostheses, pharmaceutical formulations, coatings, etc., to achieve great commercial value, increase the rate of osteogenesis, increase proliferation and osteogenic differentiation ability.
Active Publication Date: 2022-08-05
DENTAL HOSPITAL SHANXI MEDICAL UNIV
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Problems solved by technology
[0005] At present, there is no method of loading bovine pancreatic β cell exosomes on the surface of implants to form Ti-Exo-TiO 2 Composite structure to improve implant osseointegration rate related reports
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Embodiment 1
[0038] Example 1 Preparation and properties of titanium-based implants
[0039] 1.1 Preparation of bovine pancreatic β-cell exosomes
[0040] ①Isolation and culture of bovine pancreatic β cells
[0041] a. The bovine pancreas was taken from the slaughterhouse, stored in an ice box at low temperature, and sent to the biosafety laboratory within 6 hours.
[0042] b. In a sterile environment, after rinsing the bovine pancreas with 75% alcohol for three times, the bovine pancreas with a weight of 10 g was cut out and soaked in 20 mL of standard phosphate balanced salt buffer solution (pH=7.4).
[0043] c. Place the washed pancreas in a 6cm petri dish, cut into pieces, add 5mL of collagenase type IV, digest at 37°C for 45min, pipet the sample several times with a 1mL pipette tip during this period, place the above sample on a constant temperature incubation shaker, 37 Shake at 30 rpm for 10 minutes at ℃ to fully contact the enzyme with the sample to achieve the best digestion eff...
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Abstract
The invention discloses a titanium-based implant for promoting osseointegration, a preparation method and application thereof, and belongs to the field of biological implants. After the surface of the pure titanium-based implant is loaded with bovine pancreatic beta cell exosomes by chemical fixation, it is reused Deposition of TiO on the Surface of Exo‑Ti Implants by Atomic Layer Deposition 2 Nanolayered thin films, forming Ti‑Exo‑TiO 2 "Sandwich" composite structure, developed and prepared titanium-based implants loaded with bovine pancreatic β-cell exosomes; Ti‑Exo‑TiO 2 The nanolayered films are uniform and highly conformal, with better hydrophilicity, antibacterial properties, and corrosion resistance. The titanium-based implant can significantly increase the proliferation and osteogenic differentiation capacity of bone marrow mesenchymal stem cells, improve the osteogenesis rate on the implant surface, and significantly improve the bone-implant contact rate and the removal torque of the implant. The titanium-based implant prepared by the invention is suitable for industrial popularization and application, and provides a new product for the field of medical implanted human body materials.
Description
technical field [0001] The invention relates to the field of biological implants, in particular to a titanium-based implant for promoting osseointegration and a preparation method and application thereof. Background technique [0002] Dental implants have become the first choice for restoration of dentition defects and missing teeth. At present, a major problem faced by dental implants is the lack of initial stability of the implants and the failure of osseointegration caused by continuous fretting, which eventually leads to the early fall of the implants. In elderly people with osteoporosis, diabetes, periodontal disease and smoking, the reduction of implant osseointegration caused by various systemic diseases has become the main risk of artificial dental implant failure. Therefore, how to improve the osseointegration rate of implants and expand the indications of dental implants is still an urgent problem to be solved in the treatment of artificial dental implants. [00...
Claims
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IPC IPC(8): A61L27/38A61L27/06A61L27/30A61L27/50A61L27/54C23C16/455C23C16/40
CPCA61L27/3804A61L27/3865A61L27/06A61L27/306A61L27/50A61L27/54C23C16/45555C23C16/405A61L2430/12A61L2300/412A61L2400/18A61L2420/02A61L2400/12
Inventor 王兴李晖菲赵彬田春瑞
Owner DENTAL HOSPITAL SHANXI MEDICAL UNIV