A kind of porous composite bone cement and preparation method thereof

A technology of bone cement and dehydrating agent, used in surgical adhesives, prostheses, operations, etc., can solve the problems of ingrowth of bone cells, affecting the mechanical properties and biocompatibility of bone cement, and low interfacial adhesion, achieving Good biocompatibility and effects of biodegradability, non-immunogenic biocompatibility, good biocompatibility

Active Publication Date: 2022-07-22
山东明德生物医学工程有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a porous composite bone cement and its preparation method, which overcomes the above-mentioned deficiencies in the prior art, can be used in orthopedics, osteoporotic fracture fixation, bone defect filling, etc., and solves the problem of traditional bone cement and autologous bone cement. Low interfacial bonding between bones, inability of bone cells to grow in, and the residual reactants of porogen after the current porous bone cement is cured affect the mechanical properties and biocompatibility of bone cement

Method used

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  • A kind of porous composite bone cement and preparation method thereof
  • A kind of porous composite bone cement and preparation method thereof
  • A kind of porous composite bone cement and preparation method thereof

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Effect test

Embodiment 1

[0024] A porous composite bone cement is mainly composed of 20g powder and 10mL liquid. The powder is mainly composed of the following raw materials: PMMA 11.98g, degradable biological material 2g, barium sulfate 6g, benzoyl peroxide 0.02g , the above-mentioned raw materials are evenly mixed to obtain bone cement powder; the liquid is mainly composed of the following raw materials: methyl methacrylate 9.45ml, N,N-dimethyl-p-toluidine 0.5mL, hydroquinone 0.05mL, the above-mentioned raw materials Mix to obtain the bone cement liquid.

[0025] The degradable biomaterial is a copolymer with three branched structures obtained by the polymerization of polyethylene glycol and citric acid through esterification reaction, and the specific preparation method is as follows: EDCI, DMAP, citric acid, polyethylene glycol (Molecular weight is 200) mixed according to the molar ratio of 2:0.5:1:3, and dissolved in n-butanol solvent, reacted at 40 ° C for 6 hours, separated after the reaction, ...

Embodiment 2

[0028] A porous composite bone cement is mainly composed of 20g powder and 10mL liquid. The powder is mainly composed of the following raw materials: PMMA 10.98g, degradable biological material 3g, barium sulfate 6g, benzoyl peroxide 0.02g , the above-mentioned raw materials are evenly mixed to obtain bone cement powder; the liquid is mainly composed of the following raw materials: methyl methacrylate 9.3ml, N,N-dimethyl-p-toluidine 0.5mL, hydroquinone 0.2mL, the above-mentioned raw materials Mix to obtain the bone cement liquid.

[0029] The degradable biological material is a copolymer with three branched structures mainly obtained by the polymerization of polyethylene glycol and citric acid through an esterification reaction, and the specific preparation method is as follows: N,N-dicyclohexylcarbodiimide , tetrabutyl titanate, citric acid, polyethylene glycol (molecular weight 400) were mixed according to the molar ratio of 2:0.5:1:3, and dissolved in n-butanol solvent, rea...

Embodiment 3

[0032] A porous composite bone cement is mainly composed of 20g powder and 10mL liquid. The powder is mainly composed of the following raw materials: PMMA 9.98g, degradable biological material 4g, barium sulfate 6g, benzoyl peroxide 0.02g , the above-mentioned raw materials are evenly mixed to obtain bone cement powder; the liquid is mainly composed of the following raw materials: methyl methacrylate 9.945ml, N,N-dimethyl-p-toluidine 0.05mL, hydroquinone 0.005mL, the above-mentioned raw materials Mix to obtain the bone cement liquid.

[0033] The degradable biological material is a copolymer with three branched structures mainly obtained by the polymerization of polyethylene glycol and citric acid through esterification reaction, and the specific preparation method is as follows: EDCI, tetraisopropyl titanate, citric acid , polyethylene glycol (molecular weight: 600) is mixed according to the molar ratio of 2:0.5:1:3, and dissolved in n-butanol solvent, reacted at 40 ° C for 8...

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Abstract

The invention relates to the technical field of biomedical materials, in particular to a porous composite bone cement and a preparation method thereof. The porous composite bone cement is mainly composed of powder and liquid. The ratio of powder to liquid is 2:1 g / mL. The powder is mainly composed of the following raw materials by mass percentage: methacrylic acid polymerization 29.5-84% of biodegradable materials, 10-40% of degradable biological materials, 5-30% of barium sulfate, 0.01-0.5% of benzoyl peroxide; the liquid mainly consists of the following raw materials by mass: methyl methacrylate 93 -99.45%, N,N-dimethyl-p-toluidine 0.5-5%, hydroquinone 0.05-2%. The invention solves the problems of low interfacial bonding force between traditional bone cement and autologous bone, inability of bone cells to grow, and the influence of residual reactants of pore-forming agent after the current porous bone cement is solidified on the mechanical properties and biocompatibility of bone cement.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a porous composite bone cement and a preparation method thereof. Background technique [0002] Bone cement is the common name for bone cement, a medical material used in orthopedic surgery. PMMA bone cement is an injectable filling and adhesive material that was first used in prosthetic replacements. At present, it has been widely used in clinical orthopedics, especially in the aspect of spinal repair and shaping. [0003] PMMA bone cement has many advantages as a filling material in orthopedic surgery: good injectability; good viscosity, which can be well bonded to bones and implants; excellent mechanical strength; fast curing time Wait. At the same time, as an injection material for human body, PMMA bone cement has obvious shortcomings. PMMA bone cement is a synthetic polymer. This material has poor compatibility with bone and cannot form a good bond with the b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/04A61L24/06A61L24/00A61L27/56A61L27/50A61L27/18A61L27/16C08G65/332
CPCA61L24/046A61L24/06A61L24/0036A61L24/001A61L27/56A61L27/50A61L27/18A61L27/16C08G65/3322A61L2430/02C08L71/02C08L33/12
Inventor 李朝阳李梦霞崔永顺吕维加
Owner 山东明德生物医学工程有限公司
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