Piezoelectric electret drug delivery patch for transdermal drug delivery in combination with pressing or flapping as well as preparation method and application of same

A piezoelectric electret, transdermal drug delivery technology, applied in the direction of drug devices, other medical devices, etc., can solve the problems that the electret polarization voltage cannot be reached, it is difficult to control, etc., and it is beneficial to percutaneous penetration , Improving liquidity and expanding the effect of channels

Pending Publication Date: 2021-11-02
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the control voltage output by the microprocessor system cannot reach the polarization voltage of the electret, it is difficult to effectively regulate the electrostatic field and micro-current in the electret

Method used

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  • Piezoelectric electret drug delivery patch for transdermal drug delivery in combination with pressing or flapping as well as preparation method and application of same
  • Piezoelectric electret drug delivery patch for transdermal drug delivery in combination with pressing or flapping as well as preparation method and application of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] This embodiment provides a piezoelectric electret drug delivery patch combined with contact pressure or tapping for transdermal drug delivery. Body layer and drug layer2.

[0076] The piezoelectric electret 4 adopted in the piezoelectric electret layer is a polypropylene piezoelectric electret;

[0077] Plating silver on one side surface of the piezoelectric electret 4 by chemical vapor deposition to obtain a piezoelectric electret layer;

[0078] The thickness of the piezoelectric electret layer is 200 μm, wherein the average thickness of the metal electrode 3 is 400 nm, and the area of ​​the metal electrode 3 is smaller than the area of ​​the piezoelectric electret 4;

[0079] The drug layer 2 is medical gauze soaked in ointment, the covering layer 1 is a medical bandage, and the area of ​​the covering layer 1 is larger than the area of ​​the piezoelectric electret layer;

[0080] The piezoelectric electret drug delivery patch can be cut according to the actual requ...

Embodiment 2

[0082] This embodiment provides a piezoelectric electret drug delivery patch combined with contact pressure or tapping for transdermal drug delivery. Body layer and drug layer2.

[0083] The piezoelectric electret 4 adopted in the piezoelectric electret layer is a polypropylene piezoelectric electret;

[0084] Plating silver on one side surface of the piezoelectric electret 4 by magnetron sputtering to obtain a piezoelectric electret layer;

[0085] The thickness of the piezoelectric electret layer is 500 μm, wherein the average thickness of the metal electrode 3 is 100 nm, and the area of ​​the metal electrode 3 is less than or equal to the area of ​​the piezoelectric electret 4;

[0086] The drug layer 2 is medical gauze soaked in ointment, the covering layer 1 is a medical bandage, and the area of ​​the covering layer 1 is larger than the area of ​​the piezoelectric electret layer;

[0087] The piezoelectric electret drug delivery patch can be cut according to the actual ...

Embodiment 3

[0089] This embodiment provides a piezoelectric electret drug delivery patch combined with contact pressure or tap transdermal drug delivery, the piezoelectric electret drug delivery patch includes a covering layer 1, a piezoelectric electret Body layer and drug layer2.

[0090] The piezoelectric electret 4 adopted in the piezoelectric electret layer is a polypropylene piezoelectric electret;

[0091] plating gold on one surface of the piezoelectric electret by chemical vapor deposition to obtain a piezoelectric electret layer;

[0092] The thickness of the piezoelectric electret layer is 20 μm, wherein the average thickness of the metal electrode 3 is 50 nm, and the area of ​​the metal electrode 3 is smaller than the area of ​​the piezoelectric electret 4;

[0093] The drug layer 2 is not a medical gauze soaked in ointment, but a drug directly applied on the skin surface; the covering layer 1 is a medical bandage.

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Abstract

The invention provides a piezoelectric electret drug delivery patch for transdermal drug delivery in combination with pressing or flapping as well as a preparation method and application of the same. The piezoelectric electret drug delivery patch comprises a covering layer, a piezoelectric electret layer and a drug layer which are sequentially arranged in a stacked mode. And the piezoelectric electret layer comprises a piezoelectric electret and a metal electrode combined with the piezoelectric electret. The piezoelectric electret drug delivery patch generates micro-current pulses through touching or beating, the fluidity of skin lipoid is improved, drug molecules enter a channel penetrating through the skin cuticle and expand, and then the transdermal permeation efficiency of the drug is obviously improved.

Description

technical field [0001] The invention belongs to the technical field of transdermal drug delivery preparations, in particular to a piezoelectric electret drug delivery patch and its preparation method and application, in particular to a piezoelectric electret combined with contact pressure or tapping for transdermal drug delivery Drug delivery patch and its preparation method and application. Background technique [0002] Drugs applied on the surface of the skin enter the systemic circulation by penetrating the skin by themselves, or use a certain method to make the drug enter the systemic circulation through the skin at a constant or near constant rate, thereby producing systemic or local therapeutic effects. This method of administration is called Transdermal administration. [0003] Drugs applied on the surface of the skin are conducted to the inside of the skin through natural penetration, but due to the barrier effect of the stratum corneum of the skin, the conduction e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/00A61M2037/0007
Inventor 方鹏曹江浪李光林
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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