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Method and system for analyzing and monitoring viral genome variation

A technology for virus genome and mutation analysis, applied in monitoring methods and systems, in the field of virus genome mutation analysis, which can solve problems such as long vaccine development cycles

Active Publication Date: 2021-11-02
HUNAN UNIV
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Problems solved by technology

[0003] However, the vaccine development cycle is long, from the emergence of SARS-CoV-2 to the first batch of vaccines in use, it took about a year

Method used

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  • Method and system for analyzing and monitoring viral genome variation
  • Method and system for analyzing and monitoring viral genome variation
  • Method and system for analyzing and monitoring viral genome variation

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Embodiment Construction

[0055] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0056] like figure 1 As shown, in the embodiment of the present invention, a flow chart of a virus genome mutation analysis and monitoring method is proposed, and the mutation analysis process specifically includes the following steps:

[0057] Step S101, obtaining a reference gene sequence and a genome sequence to be analyzed, and performing quality control on the genome sequence to be analyzed to obtain a whole genome sequence set with good sequencing quality. In the embodiment of the present invention, the acquired genome sequence is cyclically scanned, and the number of unknown bases (N string...

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Abstract

The invention belongs to the field of bioinformatics and biomedicine, and particularly relates to a method and a system for analyzing and monitoring viral genome variation. According to the method, after sequence comparison, whole-gene annotation is carried out to obtain coding gene information, translation comparison is carried out, mutation types are analyzed according to a genetic codon table, mutation sites, types and frequencies of genomes are obtained, high-frequency mutation sites are counted, virus strains at different times and in different areas are collected, and the distribution characteristics of the high-frequency mutation sites in time and regions are analyzed, and the high-frequency mutation sites located at the immune epitopes and nearby the immune epitopes are screened so as to realize virus genome variation analysis and monitoring.

Description

technical field [0001] The invention belongs to the fields of bioinformatics and biomedicine, and in particular relates to a method and system for analyzing and monitoring virus genome variation. Background technique [0002] At the end of 2019, the outbreak of the new crown epidemic caused by SARS-CoV-2 brought great harm and challenges to the world's public health, economy, and sustainable social development. As SARS-CoV-2 became widespread in the human population, its genome continued to evolve and mutate. Some mutations confer new genetic characteristics on the virus, such as affecting infectivity and vaccine efficacy. Previous related studies have shown that some mutation sites will affect the infection characteristics of the virus and the immune protection against neutralizing antibodies and even vaccines. [0003] However, the vaccine development cycle is long, from the emergence of SARS-CoV-2 to the first batch of vaccines being put into use, it took about a year. ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/30G16B20/50G16B30/10G16B40/00
CPCG16B20/30G16B20/50G16B30/10G16B40/00Y02A90/10
Inventor 葛行义周秩建邱烨叶生宝
Owner HUNAN UNIV
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