Application of lactobacillus plantarum with cholesterol lowering function

A Lactobacillus plantarum and cholesterol-lowering technology, applied in the direction of Lactobacillus, medical preparations containing active ingredients, applications, etc., can solve problems such as high cholesterol, unreasonable diet, and rising incidence of cardiovascular diseases, and reduce liver weight ratio, no risk of antibiotic transfer, and good cholesterol-lowering ability

Pending Publication Date: 2021-11-05
湖北均瑶大健康饮品股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the improvement of people's living standards, people tend to pursue high-nutrition diets, resulting in unreasonable diets and excessive dietary cholesterol intake, leading to an increase in the incidence of cardiovascular diseases year by year.

Method used

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  • Application of lactobacillus plantarum with cholesterol lowering function
  • Application of lactobacillus plantarum with cholesterol lowering function
  • Application of lactobacillus plantarum with cholesterol lowering function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: the cholesterol-lowering function of Lactobacillus plantarum J26

[0021] The assay steps of the cholesterol-lowering effect of Lactobacillus plantarum J26 are as follows:

[0022] (1) Take Lactobacillus plantarum J26 and other 24 strains of Lactobacillus preserved in the laboratory, as well as E.coliATCC 25922, S.aureus ATCC 25923 and Salmonella ATCC 14028 preserved in the laboratory, and inoculate them into MRS medium and LB culture respectively Base and NB medium, after growing to the logarithmic phase, isolate a single colony, and subculture for two generations to become the working solution. The working solution is mixed with glycerol to preserve the species, and stored at -80°C.

[0023] (2) Cholesterol standard curve drawing

[0024] Take 0.1, 0.2, 0.3, 0.4, 0.5, 0.6 mL of cholesterol stock solution respectively in clean test tubes, add o-phthalaldehyde and concentrated sulfuric acid successively after nitrogen blowing, mix well, after standing sti...

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PUM

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Abstract

The invention discloses application of lactobacillus plantarum with a cholesterol lowering function, and belongs to the field of probiotic functions. The invention aims to alleviate hyperlipidemia caused by excessive intake of cholesterol, which further cause various cardiovascular diseases, and cause certain threats to human health. According to the invention, the cholesterol lowering ability of the Lactobacillus plantarum J26 is evaluated through the in vitro experiment and the animal experiment, and the results prove that the Lactobacillus plantarum J26 has good cholesterol lowering ability in vitro, can reduce the cholesterol content and the triglyceride content in the serum of a high fat mouse in vivo, and can reduce the liver weight ratio of the mouse. The lactobacillus plantarum can be used for preparing health-care products or medicines for reducing blood fat.

Description

technical field [0001] The invention belongs to the functional field of probiotics, and in particular relates to the application of a strain of Lactobacillus plantarum with the function of lowering cholesterol. Background technique [0002] Excessive cholesterol content in the body will affect the normal life of the human body, cause cardiovascular disease, and cause health risks. High levels of serum cholesterol are more likely to cause cardiovascular and cerebrovascular diseases. For every 1% increase in serum cholesterol levels, the incidence of cardiovascular and cerebrovascular diseases increases by 3%. Except for a small amount of self-synthesis of cholesterol in the human body, most of it comes from food. In 1989, the American Diet and Health Research Council proposed to limit the cholesterol in food. However, with the improvement of people's living standards, people often pursue high-nutrition diets, resulting in unreasonable diets and excessive dietary intake of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A61K35/747A61P3/06
CPCA23L33/135A61K35/747A61P3/06A23V2002/00A23V2400/169A23V2200/3262
Inventor 姜毓君满朝新张宇杨茉苏悦
Owner 湖北均瑶大健康饮品股份有限公司
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