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Method for extracting and separating liquiritin and glycyrrhizic acid

A technology for liquiritin and glycyrrhizic acid, which is applied in the field of extraction and separation of liquiritin and glycyrrhizic acid, can solve problems such as difficult separation of target products, and achieve the effect of saving costs

Active Publication Date: 2021-11-05
INST OF BAST FIBER CROPS CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is a big problem with these methods
Due to the non-volatility of ionic liquids, it is difficult to separate the target product from the extractant

Method used

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  • Method for extracting and separating liquiritin and glycyrrhizic acid
  • Method for extracting and separating liquiritin and glycyrrhizic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0034] The licorice was extracted by the method of the above step S1. In Examples 1-5, other extraction conditions were the same, specifically: solid-liquid ratio 1g:40mL, extraction temperature 50°C, extraction time 30min, the difference was that the concentration of the ionic liquid was different . After the extraction, the extraction effects of liquiritin and glycyrrhizic acid were tested respectively, as shown in Table 1.

[0035] Table 1 Effect of different concentrations of ionic liquids on the extraction rate of liquiritin and glycyrrhizic acid

[0036] Example Ionic liquid concentration (%) Extraction rate of liquiritin (mg / g) Extraction rate of glycyrrhizic acid (mg / g) 1 20 5.52 15.00 2 40 5.71 15.30 3 50 5.79 19.82 4 60 6.61 25.04 5 80 6.22 18.79

Embodiment 6-10

[0038] Glycyrrhizae was extracted by the method of the above step S1. In Examples 6-10, other extraction conditions were the same, specifically: ionic liquid concentration 60%, extraction temperature 50°C, extraction time 30 minutes, the difference was that the solid-liquid ratio was different. After the extraction, the extraction effects of liquiritin and glycyrrhizic acid were tested respectively, as shown in Table 2.

[0039] The influence of table 2 different solid-liquid ratios on the extraction rate of liquiritin and glycyrrhizic acid

[0040] Example Solid to liquid ratio (g / ml) Extraction rate of liquiritin (mg / g) Extraction rate of glycyrrhizic acid (mg / g) 6 1:100 7.81 25.47 7 1:50 11.27 25.58 8 1:40 8.10 20.38 9 1:25 7.21 16.46 10 1:20 7.13 14.30

Embodiment 11-15

[0042] Using the method of the above step S1, the licorice is extracted. In Examples 11-15, the other conditions are the same, specifically: the concentration of the ionic liquid is 60%, the solid-liquid ratio is 1g:50mL, and the extraction time is 30min. The difference is that the extraction The temperature is different. After the extraction, the extraction effects of liquiritin and glycyrrhizic acid were tested respectively, as shown in Table 3.

[0043] Table 3 Effects of different extraction temperatures on the extraction rate of liquiritin and glycyrrhizic acid

[0044] Example temperature(℃) Extraction rate of liquiritin (mg / g) Extraction rate of glycyrrhizic acid (mg / g) 11 40 9.41 23.33 12 45 10.78 23.94 13 50 11.22 24.89 14 55 9.65 28.29 15 60 8.61 26.78

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Abstract

The invention discloses a method for extracting and separating liquiritin and glycyrrhizic acid, which comprises the following steps: S1, mixing ionic liquid with licorice powder, and extracting the liquiritin and the glycyrrhizic acid; S2, after extraction is completed, carrying out solid-liquid separation, taking supernate, adding a NaOH solution, then increasing the temperature to 65-80 DEG C, obtaining an ionic liquid phase containing the liquiritin and a water phase containing the glycyrrhizic acid, and separating the water phase and the ionic liquid phase; wherein the ionic liquid is temperature response type ionic liquid. According to the method, the temperature response type ionic liquid is used as the extracting agent, the system temperature is changed after extraction is completed, the liquiritin and the glycyrrhizic acid can be separated, the method is simple, and the used ionic liquid can be recycled and reused, which is environmentally friendly.

Description

technical field [0001] The invention relates to the field of extracting liquiritin and glycyrrhizic acid, more specifically, relates to a method for extracting and separating liquiritin and glycyrrhizic acid. Background technique [0002] Licorice is the dry root or rhizome of the perennial herbaceous leguminous plant Licorice. It is a kind of tonic Chinese herbal medicine. [0003] Modern chemical studies have shown that licorice mainly contains flavonoid glycosides (licyrrhizin, isoliquiritin, etc.) and glycyrrhizic acid components, among which the content of glycyrrhizin and glycyrrhizic acid is the highest. Liquiritin belongs to flavonoids and has neuroprotective, anti-oxidative and anti-myocardial fibrosis effects; glycyrrhizic acid belongs to triterpenoid saponins and has pharmacological effects such as anti-inflammation, anti-virus and liver protection. Traditional methods for extracting liquiritin and glycyrrhizic acid usually use organic solvents or water as extrac...

Claims

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Application Information

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IPC IPC(8): C07H15/26C07H1/08C07J63/00
CPCC07H15/26C07H1/08C07J63/008Y02P20/54
Inventor 谭志坚余旺易永建曾粮斌杨媛茹汪洪鹰
Owner INST OF BAST FIBER CROPS CHINESE ACADEMY OF AGRI SCI
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