Application of sialic acid to regulation of dyslipidemia caused by abnormal expression of gene causing Alzheimer's disease

A blood lipid metabolism and sialic acid technology, applied in the biological field, can solve the problem that animal models cannot simulate human AD diseases well, and achieve the effect of wide applicability, broad application prospects, and promotion of normal recovery

Pending Publication Date: 2021-11-09
CABIO BIOTECH WUHAN CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The animal models in previous studies could not well simulate the progressive process of human AD disease, but the emergence of the APP / PS1 double transgenic mouse model solved this problem. The APP / PS1 double transgenic mouse model has two gene mutations, Mutation of the APP gene and deletion of exon 9 of the PS1 gene, this mouse model can better show early mild cognitive impairment, which is also a typical behavioral and pathological change in the process of AD

Method used

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  • Application of sialic acid to regulation of dyslipidemia caused by abnormal expression of gene causing Alzheimer's disease
  • Application of sialic acid to regulation of dyslipidemia caused by abnormal expression of gene causing Alzheimer's disease
  • Application of sialic acid to regulation of dyslipidemia caused by abnormal expression of gene causing Alzheimer's disease

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Effect test

Embodiment 1

[0030] 1. Test substance

[0031] Low dose of sialic acid: 17mg / kg / day body weight, medium dose of sialic acid: 84mg / kg / day body weight, high dose of sialic acid: 420mg / kg / day body weight.

[0032] 2. Sample settings

[0033] In this experiment, the double transgenic model of APP / PS1 was used. This model is a commonly used AD mouse model, which can produce a large amount of Aβ in the brain.

[0034] According to the table below, 2×Tg(APP / PS1)-AD male mice (hereinafter referred to as AD mice) were grouped with blank control male mice. Where L is low dose, M is medium dose, and H is high dose (WT is normal mice).

[0035] Table 1 Grouping of AD male mice and blank control male mice

[0036]

[0037] 3. Experimental steps

[0038] (1) The test substance and the placebo were mixed into the mouse feed respectively, and the mice were treated in a free-feeding manner, and the feed was changed every day.

[0039] (2) The blank control group and the test model group were given co...

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Abstract

The invention relates to application of sialic acid to regulation of dyslipidemia caused by abnormal expression of genes causing Alzheimer's disease, in particular to application of the sialic acid to regulation of dyslipidemia caused by abnormal expression levels of APP and PS1 genes. The research finds that the sialic acid is applied to APP / PS1 transgenic mice, and after the sialic acid is supplemented, the expression levels of apolipoprotein A and apolipoprotein B are improved, which indicates that the sialic acid can effectively regulate dyslipidemia caused by abnormal expression of the APP and PS1 genes. According to the invention, the sialic acid is used as a diet intervention mode or is prepared into a medicinal preparation to regulate abnormal blood lipid metabolism, has the advantages of rich sources, small toxic and side effects, wide applicability to people and the like, can be used singly and also be combined flexibly, and has a wide application prospect in regulation of abnormal blood lipid metabolism caused by abnormal expression of the APP and PS1 genes.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the application of sialic acid in regulating abnormal blood lipid metabolism caused by abnormal expression of genes causing Alzheimer's disease. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD) is a chronic degenerative disease of the central nervous system, commonly known as senile dementia, is the most common type of senile dementia, characterized by memory loss and cognitive dysfunction, and the condition is progressively aggravated . Among the elderly over 60 years old, the probability of suffering from this disease is high, and the prevalence rate will increase rapidly with the aging of the population. AD can last for 20 years, the condition gradually worsens, and gradually loses the ability to live independently. 10 to 20 years after the onset, it dies due to complications, which brings heavy burden and pain to individuals, families, and society. ...

Claims

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Application Information

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IPC IPC(8): A61K31/7012A61P25/28A61P3/06A23L33/125A23L2/52A23G3/42A23G3/36A21D13/062
CPCA61K31/7012A61P25/28A61P3/06A23L33/125A23L2/52A23G3/42A23G3/364A21D13/062A23V2002/00A23V2200/322A23V2200/326A23V2250/5438
Inventor 汪志明李翔宇丰珂珏肖敏陆姝欢
Owner CABIO BIOTECH WUHAN CO LTD
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