Imide derivatives ar Salts thereof

Abstract

An amide derivative represented by the following formula: wherein the ring B is a heteroaryl group; X is a bond or a lower alkylene group; and R is a hydrogen atom, a halogen atom, a lower alkyl group, an amino group, an aryl lower alkyl group or a haloaryl lower alkyl group, or a salt thereof, is disclosed. A therapeutic agent for diabetes mellitus having both an insulin secretion promoting action and an insulin sensitivity potentiating action and also having anti-obesity and anti-hyperlipemia actions due to a selective stimulating action to beta3-receptors, is also disclosed.

Description

technical field

[0001] The present invention relates to a class of medicines, more specifically to novel amide derivatives or their salts and therapeutic agents for treating diabetes. Background technique

[0002] Diabetes mellitus, a disease accompanied by symptoms of persistent hyperglycemia, is now thought to be due to a number of environmental and genetic factors. The main control factor of blood sugar is insulin, and it has been recognized that hyperglycemia is caused by a lack of insulin or an excess of factors that inhibit insulin response (such as genetic reasons, lack of exercise, obesity and stress).

[0003] There are two main types of diabetes. One is insulin-dependent diabetes mellitus (IDDM) caused by autoimmune diseases that reduce the function of pancreas to secrete insulin, and the other is non-insulin-dependent diabetes mellitus (IDDM) that is caused by the fatigue of continuous high-level secretion of insulin by the pancreas, which reduces the function of...

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