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Anti-aging composition as well as preparation method and application thereof

A composition and anti-aging technology, applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., to achieve the effects of reducing protein glycosylation, enhancing transdermal absorption, and mild effect

Pending Publication Date: 2021-11-16
COSMAX CHINA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the problem that existing anti-aging compositions only delay skin aging from the perspective of anti-oxidation and anti-glycation, ignoring the impact of chronic inflammation on aging, the present invention proposes an anti-aging composition that reduces chronic inflammation and resists free radicals. , Reduce protein carbonylation in three ways to slow down the aging process

Method used

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  • Anti-aging composition as well as preparation method and application thereof
  • Anti-aging composition as well as preparation method and application thereof
  • Anti-aging composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] In the following examples and comparative examples, the specific preparation process adopted by an anti-aging composition is as follows:

[0053] 1) Clean the flower dregs of Rosa rosea, add 3 times the mass of deionized water to break up the homogenate, use a high-pressure homogenizer at 200MPa, homogenize for 7 times, centrifuge to get the supernatant, concentrate under reduced pressure to one-fifth to One-half, dry into powder, add 1.5 mass times of solvent and dissolve evenly to obtain the Rosa rosea flower extract; the solvent is deionized water, and the mass ratio of butanediol is 1:1;

[0054] 2) Clean the North American pine bark, add 6 times the mass of deionized water, use a homogenizer to carry out wet ultrafine grinding, centrifuge, take the supernatant and concentrate it under reduced pressure to one-third, and dry it in an oven. Powder, that is, North American pine bark extract;

[0055] 3) Lactobacilli were inoculated in a sterile medium, cultured by ana...

Embodiment 2

[0063] Embodiment 2: the preparation of anti-aging essence

[0064] The present invention also prepared the anti-aging essence prepared in the above-mentioned Example 9, the composition and the number of parts are shown in Table 4.

[0065] The preparation method is as follows:

[0066] (1) Mix water, chelating agent, humectant, pH regulator, and antioxidant, heat to 70-80°C to dissolve to obtain phase A, keep warm for later use;

[0067] (2) Mix the solvent, solubilizer, and antibacterial agent evenly, heat to 40-45°C to obtain phase C, and keep it warm for later use;

[0068] (3) Put phase B as a thickener into phase A, homogenize for 3 minutes, control the temperature at 70-80°C, and confirm the dispersion state;

[0069] (4) Cool to 40-45°C in the material obtained in step (3), add phase C, and homogenize for 3 minutes;

[0070] (5) Add phase D to the material obtained in step (4), and homogenize for 3-5 minutes to obtain Soothing Repair Essence Sample 1.

[0071] The ...

experiment example 1

[0075] Experimental Example 1: Cytotoxicity Test

[0076] MTT assay is an experimental method widely used in the detection of cytotoxicity or cell proliferation by measuring the number of living cells. The detection principle is that succinate dehydrogenase in the mitochondria of living cells can make the water-soluble yellow salt MTT (3- (4,5-dimethylthiazole-2)-2,5-diphenyltetrazolium bromide) is reduced to water-insoluble blue formazan and deposited in cells, while dead cells have no such function. The generated crystalline formazan is generally added to DMSO (dimethyl sulfoxide), and the absorbance is measured after dissolution. The specific experimental method is in a 96-well plate according to 1X10 4 Inoculate 100 μl of DMEM medium containing 10% bovine serum and 100 μl of keratinocytes (HaCaT) at a density of one per well, and replace with serum-free medium after 24 hours of culture. The examples and comparative examples (diluted with deionized water) of different con...

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Abstract

The invention discloses an anti-aging composition as well as a preparation method and application thereof. The composition comprises a lactobacillus fermentation lysate, a rosa multiflora flower extract and a North America arbor bark extract in a mass ratio of (1-10):(0.1-2):(0.1-3). The composition disclosed by the invention not only can enhance the transdermal absorption of the skin in a certain proportion range to play a synergistic effect. According to the invention, aging is slowed down from the three aspects of anti-inflammation, anti-oxidation and anti-saccharification, the sensitivity of sensitive skin is reduced, and the skin is healthy and bright and conforms to the natural and sustainable concept; besides, the rosa multiflora flower residues and the North America arbor bark which should be abandoned are fully utilized.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to an anti-aging composition and its preparation method and application. Background technique [0002] With the development of society, people pay more and more attention to their personal skin condition. Aging is a naturally occurring life process. Environmental pollution, lifestyle, and work and rest rules will all affect the aging process. The anti-aging effect of cosmetics is an eternally pursued topic. [0003] The skin is the first barrier of human immunity. There are a large number of microorganisms on the surface of the human body, including bacteria, fungi, viruses, etc. These microorganisms play an important role in maintaining the ecological balance of the skin, self-purification, and participating in the implementation of skin physiological functions. Dysbiosis of the skin microbiota leads to functional immunodeficiency, triggering the body's own nonspecific but tim...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/9789A61K8/9767A61Q19/08
CPCA61K8/99A61K8/9789A61K8/9767A61Q19/08A61K2800/5922A61K2800/85A61K2800/805
Inventor 罗丹周秋娜胡霞云金荣熙申彦晟金延埈
Owner COSMAX CHINA INC
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